"The U.S. Food and Drug Administration today expanded the approved uses of Abraxane (paclitaxel protein-bound particles for injectable suspension, albumin-bound) to treat patients with late-stage (metastatic) pancreatic cancer.
In clinical trials, the maximum single dose of ETHYOL (amifostine) was 1300 mg/m2. No information is available on single doses higher than this in adults. In the setting of a clinical trial, pediatric patients have received single ETHYOL (amifostine) doses of up to 2700 mg/m2. At the higher doses, anxiety and reversible urinary retention occurred.
Administration of ETHYOL (amifostine) at 2 and 4 hours after the initial dose has not led to increased nausea and vomiting or hypotension. The most likely symptom of overdosage is hypotension, which should be managed by infusion of normal saline and other supportive measures, as clinically indicated.
ETHYOL (amifostine) is contraindicated in patients with known hypersensitivity to aminothiol compounds.
Last reviewed on RxList: 8/18/2008
This monograph has been modified to include the generic and brand name in many instances.
Additional Ethyol Information
Ethyol - User Reviews
Ethyol User Reviews
Now you can gain knowledge and insight about a drug treatment with Patient Discussions.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Get the latest treatment options.