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In clinical trials, the maximum single dose of ETHYOL (amifostine) was 1300 mg/m². No information is available on single doses higher than this in adults. In the setting of a clinical trial, pediatric patients have received single ETHYOL (amifostine) doses of up to 2700 mg/m². At the higher doses, anxiety and reversible urinary retention occurred.

Administration of ETHYOL (amifostine) at 2 and 4 hours after the initial dose has not led to increased nausea and vomiting or hypotension. The most likely symptom of overdosage is hypotension, which should be managed by infusion of normal saline and other supportive measures, as clinically indicated.

ETHYOL (amifostine) is contraindicated in patients with known hypersensitivity to aminothiol compounds.

Last reviewed on RxList: 8/18/2008
This monograph has been modified to include the generic and brand name in many instances.