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Ethyol Patient Information Including Side Effects

Brand Names: Ethyol

Generic Name: amifostine (Pronunciation: AM i FOS teen)

What is amifostine (Ethyol)?

Amifostine a chemoprotectant (KEEM-o-pro-TEK-tant) that can help lessen the side effects of certain cancer chemotherapy medications or radiation treatment.

Amifostine is used to protect the kidneys from harmful effects caused by cisplatin when given to patients with ovarian cancer.

Amifostine is also used to prevent severe dry mouth caused by radiation treatment of the head and neck, which can affect the salivary gland.

Amifostine will not prevent all side effects of chemotherapy medications. However, this medication may help protect your body from some of the serious side effects that chemotherapy can cause.

Amifostine may also be used for purposes not listed in this medication guide.

What are the possible side effects of amifostine (Ethyol)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives, itching; chest tightness, difficult breathing; fever or chills; swelling of your face, lips, tongue, or throat.

Some of the side effects of amifostine may occur up to several weeks after you receive this medication.

Tell your caregiver right away if you have a serious side effect such as:

  • feeling like you might pass out;
  • chest pain, fast or slow heart rate;
  • weak or shallow breathing;
  • seizure (convulsions);
  • urinating less than usual or not at all;
  • severe skin rash on your stomach, back, or trunk;
  • redness, rash, or blisters on the palms of your hands or the soles of your feet; or
  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious side effects may include:

  • nausea, vomiting;
  • dizziness, drowsiness;
  • flushing (warmth, redness, or tingly feeling);
  • cold feeling;
  • hiccups;
  • sneezing; or
  • mild fever, general ill feeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Ethyol (amifostine) Side Effects Center for a complete guide to possible side effects

What is the most important information I should know about amifostine (Ethyol)?

You should not use amifostine if you are allergic to it.

Before you receive amifostine, tell your doctor if you have kidney disease, low or high blood pressure, low levels of calcium in your blood, heart disease, a heart rhythm disorder, congestive heart failure, circulation problems, a history of stroke, if you are dehydrated, or if you have any rash or blisters on your hands, feet, lips, or mouth.

Avoid taking blood pressure medication within 24 hours before you receive amifostine. Talk with your doctor if you are concerned about stopping the blood pressure medication for a short time.

Some of the side effects of amifostine may occur up to several weeks after you receive this medication.

Serious side effects include feeling like you might pass out, chest pain, fast or slow heart rate, weak or shallow breathing, seizure, severe skin rash, or urinating less than usual or not at all.

Side Effects Centers

Ethyol - User Reviews

Ethyol User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Ethyol sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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