Etrafon (Perphenazine and Amitriptyline) Drug Information: Medication Guide and Patient Information

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May 27, 2012

Etrafon

Anxiety »

Generalized anxiety disorder facts

Generalized anxiety disorder (GAD) is a mood disorder that is characterized by multiple and/or nonspecific worries that interfere with the person's life in some way.
The most common anxiety disorders are specific phobias. Other anxiety disorders include social anxiety disorder, panic disorder, generalized anxiety disorder, obsessive compulsive disorder, and posttraumatic stress disorder.
GAD is quite common, affecting millions of people.
While there is no single cause of GAD, there are many factors that increase the risk of developing this disorder.
Signs and symptoms of anxiety can include those that are emotional or behavioral and ways of thinking that are responses to feeling as if one is in danger.
The similarities and differences in symptoms of anxiety in adults compared to children and adolescents depend on the diagnosis.
There seem to be gender d...

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Etrafon

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Please Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

PATIENT INFORMATION

Information for Patients: This information is intended to aid in the safe and effective use of this medication. It is not a disclosure of all possible adverse or intended effects.

Given the likelihood that a substantial proportion of patients exposed chronically to neuroleptics will develop tardive dyskinesia, it is advised that all patients in whom chronic use is contemplated be given, if possible, full information about this risk. The decision to inform patients and/or their guardians must obviously take into account the clinical circumstances and the competency of the patient to understand the information provided.

Amitriptyline Hydrochloride

In manic-depressive psychosis, depressed patients may experience a shift toward the manic phase if they are treated with an antidepressant drug. Patients with paranoid symptomatology may have an exaggeration of such symptoms. The tranquilizing effect of ETRAFON (perphenazine and amitriptyline) Tablets has seemed to reduce the likelihood of this effect.

Both elevation and lowering of blood sugar levels have been reported.

The usefulness of amitriptyline in the treatment of depression has been amply demonstrated; however, it should be realized that abuse of amitriptyline among a narcotic-dependent population is not uncommon.

Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.