May 26, 2017
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"The first US clinical practice guidelines for management of primary Sjögren's system were published online July 7 in Arthritis Care & Research and include a decision tree for the use of oral disease-modifying antirheumatic drugs (DMARD"...



EVOXAC (cevimeline hcl) ®
(cevimeline hydrochloride)


Cevimeline is cis-2'-methylspiro {1-azabicyclo [2.2.2] octane-3, 5' -[1,3] oxathiolane} hydro-chloride, hydrate (2:1). Its empirical formula is C10H17NOS•HCl•½ H2O, and its structural formula is:

Evoxac (Cevimeline Hydrochloride) Structural Formula Illustration

Cevimeline has a molecular weight of 244.79. It is a white to off white crystalline powder with a melting point range of 201 to 203°C. It is freely soluble in alcohol and chloroform, very soluble in water, and virtually insoluble in ether. The pH of a 1% solution ranges from 4.6 to 5.6. Inactive ingredients include lactose monohydrate, hydroxypropyl cellulose, and magnesium stearate.

What are the possible side effects of cevimeline (Evoxac)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking cevimeline and call your doctor at once if you have any of these serious side effects:

  • shortness of breath, wheezing, or tightness in your chest;
  • chest pain, uneven heart rate;
  • attacks of severe stomach pain on the right side, extending up to your shoulder (sometimes worse after meals);
  • nausea and vomiting, bloating, fever, chills, and jaundice (yellowing of the skin or...

Read All Potential Side Effects and See Pictures of Evoxac »

What are the precautions when taking cevimeline hcl (Evoxac)?

Before taking cevimeline, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (such as asthma, chronic bronchitis, chronic obstructive pulmonary disease-COPD), certain eye conditions (such as night blindness, acute iritis, narrow-angle glaucoma), heart disease (such as chest pain, heart failure, heart attack, slow heartbeat), low or high blood pressure, liver problems, gallbladder disease (such as gallstones), kidney stones, mental/mood disorders (such as depression, psychoses,...

Read All Potential Precautions of Evoxac »

Last reviewed on RxList: 2/8/2017
This monograph has been modified to include the generic and brand name in many instances.

Evoxac - User Reviews

Evoxac User Reviews

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Here is a collection of user reviews for the medication Evoxac sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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