April 29, 2017
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Evzio

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Evzio

EVZIO®
(naloxone hydrochloride) Injection

DRUG DESCRIPTION

EVZIO (naloxone hydrochloride injection, USP) is a pre-filled, single-use auto-injector. EVZIO is not made with natural rubber latex. Chemically, naloxone hydrochloride is the hydrochloride salt of 17-Allyl-4,5α-epoxy3,14-dihydroxymorphinan-6-one hydrochloride with the following structure:

EVZIO® (naloxone hydrochloride) Structural Formula Illustration

C19H21NO4• HCl........M.W. 363.84

Naloxone hydrochloride occurs as a white to slightly off-white powder, and is soluble in water, in dilute acids, and in strong alkali; slightly soluble in alcohol; practically insoluble in ether and in chloroform.

Each 0.4 mL of EVZIO contains 2 mg naloxone hydrochloride, 3.34 mg of sodium chloride, hydrochloric acid to adjust pH, and water for injection. The pH range is 3.0 to 4.5.

Last reviewed on RxList: 10/31/2016
This monograph has been modified to include the generic and brand name in many instances.

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