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Exelon Patch

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Exelon Patch

(rivastigmine) Transdermal System

Exelon Patch


Exelon Patch (rivastigmine transdermal system) contains rivastigmine, a reversible cholinesterase inhibitor known chemically as (S)- 3-[1-(dimethylamino) ethyl]phenyl ethylmethylcarbamate. It has an empirical formula of C14H22N2O2 as the base and a molecular weight of 250.34 (as the base). Rivastigmine is a viscous, clear, and colorless to yellow to very slightly brown liquid that is sparingly soluble in water and very soluble in ethanol, acetonitrile, n-octanol and ethyl acetate.

The distribution coefficient at 37°C in n-octanol/phosphate buffer solution pH 7 is 4.27.

EXELON® (rivastigmine) Structural Formula Illustration

Exelon Patch is for transdermal administration. The patch is a four-layer laminate containing the backing layer, drug matrix, adhesive matrix and overlapping release liner (see Figure 1). The release liner is removed and discarded prior to use.

Figure 1: Cross Section of the Exelon Patch

Cross Section of the Exelon Patch - Illustration

Layer 1: Backing Film
Layer 2: Drug Product (Acrylic) Matrix
Layer 3: Adhesive (Silicone) Matrix
Layer 4: Release Liner (removed at time of use)

Excipients within the formulation include acrylic copolymer, poly(butylmethacrylate, methylmethacrylate), silicone adhesive applied to a flexible polymer backing film, silicone oil, and vitamin E.

What are the possible side effects of rivastigmine transdermal (Exelon)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using rivastigmine transdermal and call your doctor at once if you have a serious side effect such as:

  • nausea and vomiting, loss of appetite, weight loss;
  • black or bloody stools, coughing up blood or vomit that looks like blood or coffee grounds;
  • restless muscle movements in your eyes, tongue, jaw, or neck, tremor (uncontrolled shaking);
  • sudden numbness or weakness,...

Read All Potential Side Effects and See Pictures of Exelon Patch »

Last reviewed on RxList: 7/30/2013
This monograph has been modified to include the generic and brand name in many instances.


Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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