Exjade (Deferasirox) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

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Exjade

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EXJADE®
(deferasirox)

WARNING

RENAL, HEPATIC FAILURE AND/OR GASTROINTESTINAL HEMORRHAGE

Exjade may cause:

renal impairment, including failure
hepatic impairment, including failure
gastrointestinal hemorrhage

In some reported cases, these reactions were fatal. These reactions were more frequently observed in patients with advanced age, high risk myelodysplastic syndromes (MDS), underlying renal or hepatic impairment or low platelet counts ( < 50 x 10⁹/L) [see CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS]. Exjade therapy requires close patient monitoring, including measurement of:

serum creatinine and/or creatinine clearance prior to initiation of therapy and monthly thereafter; in patients with underlying renal impairment or risk factors for renal impairment, monitor creatinine and/or creatinine clearance weekly for the first month, then monthly thereafter;
serum transaminases and bilirubin prior to initiation of therapy, every two weeks during the first month and monthly thereafter.

DRUG DESCRIPTION

Exjade (deferasirox) is an iron chelating agent. Exjade tablets for oral suspension contain 125 mg, 250 mg, or 500 mg deferasirox. Deferasirox is designated chemically as 4-[3,5-Bis (2-hydroxyphenyl)-1H-1,2,4-triazol-1yl]-benzoic acid and its structural formula is

EXJADE® (deferasirox) Structural Formula Illustration

Deferasirox is a white to slightly yellow powder. Its molecular formula is C21H15N3O4 and its molecular weight is 373.4.

Inactive Ingredients: Lactose monohydrate (NF), crospovidone (NF), povidone (K30) (NF), sodium lauryl sulphate (NF), microcrystalline cellulose (NF), silicon dioxide (NF), and magnesium stearate (NF).

What are the possible side effects of deferasirox (Exjade)?

Stop using deferasirox and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

weakness or fainting, bloody or tarry stools;
coughing up blood or vomit that looks like coffee grounds;
severe stomach pain that may spread to your back;
increased thirst and urination, loss of appetite, weakness, constipation;

Read All Potential Side Effects and See Pictures of Exjade »

What are the precautions when taking deferasirox (Exjade)?

Before taking deferasirox, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, liver problems, low platelet counts.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

If you have diarrhea or vomiting, drink plenty of fluids to replace lost body water and minerals. Ask your doctor or pharmacist for more details.

Kidney function...

Read All Potential Precautions of Exjade »

Last reviewed on RxList: 8/19/2011
This monograph has been modified to include the generic and brand name in many instances.