home > drugs a-z list > exjade (deferasirox) drug center > exjade (deferasirox) drug - overdosage and contraindications

Cases of overdose (2-3 times the prescribed dose for several weeks) have been reported. In one case, this resulted in hepatitis which resolved without long-term consequences after a dose interruption. Single doses up to 80 mg/kg/day in iron overloaded β-thalassemic patients have been tolerated with nausea and diarrhea noted. In healthy volunteers, single doses of up to 40 mg/kg/day were tolerated. There is no specific antidote for Exjade. In case of overdose, induce vomiting and employ gastric lavage.

Exjade is contraindicated in patients with:

• creatinine clearance < 40 mL/min or serum creatinine > 2 times the age-appropriate upper limit of normal;
• poor performance status and high-risk myelodysplastic syndromes or advanced malignancies [see WARNINGS AND PRECAUTIONS];
• platelet counts < 50 x 10⁹/L;
• known hypersensitivity to deferasirox or any component of Exjade.

Last reviewed on RxList: 8/19/2011
This monograph has been modified to include the generic and brand name in many instances.