May 29, 2017
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"The Centers for Disease Control and Prevention has identified a cluster of newborns in Tennessee with late vitamin K deficiency bleeding (VKDB). VKDB is a serious, but preventable bleeding disorder that can cause bleeding in the brain. In each"...





Cases of overdose (2-3 times the prescribed dose for several weeks) have been reported. In 1 case, this resulted in hepatitis which resolved without long-term consequences after a dose interruption. Single doses up to 80 mg per kg per day in iron overloaded beta-thalassemic patients have been tolerated with nausea and diarrhea noted. In healthy volunteers, single doses of up to 40 mg per kg per day were tolerated. There is no specific antidote for Exjade. In case of overdose, induce vomiting and employ gastric lavage.


Exjade is contraindicated in patients with:

  • Serum creatinine greater than 2 times the age-appropriate ULN or creatinine clearance less than 40 mL/min [see WARNINGS AND PRECAUTIONS];
  • Poor performance status;
  • High-risk myelodysplastic syndromes;
  • Advanced malignancies;
  • Platelet counts less than 50 x 109 /L;
  • Known hypersensitivity to deferasirox or any component of Exjade [see WARNINGS AND PRECAUTIONS, ADVERSE REACTIONS].
This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 5/1/2017


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