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In this Article

• What is deferasirox (Exjade)?
• What are the possible side effects of deferasirox (Exjade)?
• What is the most important information I should know about deferasirox (Exjade)?
• What should I discuss with my healthcare provider before using deferasirox (Exjade)?
• How should I take deferasirox (Exjade)?
• What happens if I miss a dose (Exjade)?
• What happens if I overdose (Exjade)?
• What should I avoid while taking deferasirox (Exjade)?
• What other drugs will affect deferasirox (Exjade)?
• Where can I get more information?

What happens if I miss a dose (Exjade)?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose (Exjade)?

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of a deferasirox overdose may include nausea and diarrhea.

What should I avoid while taking deferasirox (Exjade)?

Deferasirox can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

What other drugs will affect deferasirox (Exjade)?

While you are taking deferasirox, do not take antacids that contain aluminum, such as Amphojel, Gaviscon, Maalox, Mi-Acid, Mylanta, Rulox, and others.

Do not use other iron chelating medicines such as deferoxamine (Desferal) with deferasirox unless your doctor has told you to.

Many drugs can interact with deferasirox. Below is just a partial list. Tell your doctor if you are using:

• alendronate (Fosamax), etidronate (Didronel), ibandronate (Boniva), pamidronate (Aredia), risedronate (Actonel), tiludronate (Skelid), or zoledronic acid (Reclast, Zometa);
• an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., Erythrocin, Ery-Tab), telithromycin (Ketek), and others;
• birth control pills;
• a blood thinner such as warfarin (Coumadin);
• cholesterol-lowering drugs such as atorvastatin (Lipitor), lovastatin (Mevacor), simvastatin (Zocor);
• heart or blood pressure medications such as amlodipine (Norvasc, Lotrel), diltiazem (Cartia, Cardizem), felodipine (Plendil), nifedipine (Adalat), nisoldipine (Sular), or verapamil (Calan, Covera, Isoptin).
• heart rhythm medication such as quinidine (Quinaglute, Quinidex, Quin-Release);
• HIV medicines such as indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, Kaletra), saquinavir (Invirase), and others;
• medicines used to prevent organ transplant rejection, such as cyclosporine (Gengraf, Neoral, Sandimmune) or tacrolimus (Prograf);
• an NSAID (non-steroidal anti-inflammatory drug) such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Cataflam, Voltaren), etodolac (Lodine), indomethacin (Indocin), ketoprofen (Orudis), and others;
• a sedative such as alprazolam (Xanax), diazepam (Valium), midazolam (Versed), or triazolam (Halcion); or
• steroids such as prednisone, fluticasone (Advair), mometasone (Asmanex, Nasonex), dexamethasone (Decadron, Hexadrol) and others.

This list is not complete and there are many other medicines that can interact with deferasirox. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

Where can I get more information?

Your pharmacist can provide more information about deferasirox.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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