"ORLANDO ‚Ä” Janus kinase (JAK) inhibitors are emerging as a potential treatment option for alopecia areata, eczema, and vitiligo.
These drugs "are going to change how we think about what we do," said Brett King, MD, PhD, from Yale Unive"...
EXTINA® Foam contains 2% ketoconazole USP, an antifungal agent, in a thermolabile hydroethanolic foam for topical application.
The chemical name for ketoconazole is piperazine, 1-acetyl-4-[4-[[2-(2,4-dichlorophenyl) -2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-, cis- with the molecular formula C26H28Cl2N4O4 and a molecular weight of 531.43. The following is the chemical structure:
EXTINA® Foam contains 20 mg ketoconazole per gram in a thermolabile hydroethanolic foam vehicle consisting of cetyl alcohol, citric acid, ethanol (denatured with tert-butyl alcohol and brucine sulfate) 58%, polysorbate 60, potassium citrate, propylene glycol, purified water, and stearyl alcohol pres≠surized with a hydrocarbon (propane/butane) propellant.
What are the possible side effects of ketoconazole topical?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using ketoconazole topical and call your doctor at once if you have a serious side effect such as:
- severe itching, burning, or irritation where the medicine is applied;
- oily or dry scalp, mild hair loss;
- redness, pain, or oozing of treated skin areas; or
- eye redness, swelling, or irritation.
Less serious side effects include:
- mild skin itching or...
What are the precautions when taking ketoconazole foam, 2% (Extina)?
Before using ketoconazole, tell your doctor or pharmacist if you are allergic to it; or to other azole antifungals (e.g., clotrimazole, miconazole); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history.
This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors.
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
It is not known whether this drug passes into breast milk...
Last reviewed on RxList: 3/24/2016
This monograph has been modified to include the generic and brand name in many instances.
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