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An agent for use in evaluating hypothalamic-pituitary gonadotropic function. Factrel (gonadorelin hydrochloride) injectable is available as a sterile lyophilized powder for reconstitution and administration by subcutaneous or intravenous routes.

Chemical Name: 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl -L- tyrosyl-glycyl -L- leucyl-L-arginyl-L-prolyl glycinamide hydrochloride

Factrel (gonadorelin) is C ₅₅ H ₇₅ N ₁₇ O ₁₃ HCl, as the mono- or dihydrochloride, or their mixture. The gonadorelin base has a molecular weight of 1182.33. It is a white powder, soluble in alcohol and water, hygroscopic and moisture-sensitive, and stable at room temperature. The synthetic decapeptide, Factrel (gonadorelin) , has a chemical composition and structure identical to the natural hormone, identified from porcine or ovine hypothalami.

Each Secule® vial of Factrel contains 100 or 500 mcg gonadorelin as the hydrochloride, with 100 mg lactose, USP. Each ampul of sterile diluent contains 2% benzyl alcohol in sterile water.

Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.