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What are the possible side effects of pyrimethamine and sulfadoxine (Fansidar)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using pyrimethamine and sulfadoxine and call your doctor at once if you have any of these serious side effects:

• the first sign of any skin rash, no matter how mild;
• a severe blistering, peeling, and red skin rash;
• pale skin, easy bruising or bleeding;
• feeling tired, weak, or dizzy;
• hallucinations,...

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What are the precautions when taking sulfadoxine and pyrimethamine (Fansidar)?

Before taking sulfadoxine/pyrimethamine, tell your doctor or pharmacist if you are allergic to either sulfadoxine or pyrimethamine; or to other "sulfa" drugs (such as sulfamethoxazole, sulfisoxazole); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: bleeding problems (such as low platelets), low red blood cell count (anemia), low white blood cell count, severe allergy or breathing problems (asthma), seizures, kidney problems, liver problems, low folic acid levels (such as problems with absorption of food, alcoholism), a certain enzyme problem...

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