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Fansidar Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 12/1/2015

Fansidar (sulfadoxine and pyrimethamine) Tablets is an antiparasitic drug used to treat malaria. Fansidar is available in generic form. Common side effects of Fansidar include stomach pain, feeling full, hair loss, headache, muscle weakness, depression, nervousness, ringing in your ears, sleep problems (insomnia), diarrhea, dizziness, nausea, vomiting, or loss of appetite.

The recommended dosage of Fansidar is 1 tablet once a week for adults. Dosage for children is based upon body weight. Talk to your doctor about your individual dosage recommendation. Aralen, Bactrim, Gantanol, and Septra may interact with Fansidar. Tell your doctor all medications you take. Stop taking Fansidar and call your doctor if you have any signs of a rash. Use precautionary measures such as insect repellents, and protective clothing to prevent additional mosquito bites. Drink plenty of water when taking Fansidar. You should not take Fansidar if you are pregnant or breastfeeding.

Our Fansidar (sulfadoxine and pyrimethamine) Tablets Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Fansidar in Detail - Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using pyrimethamine and sulfadoxine and call your doctor at once if you have any of these serious side effects:

  • the first sign of any skin rash, no matter how mild;
  • a severe blistering, peeling, and red skin rash;
  • pale skin, easy bruising or bleeding;
  • feeling tired, weak, or dizzy;
  • hallucinations, seizure (convulsions);
  • urinating less than usual or not at all;
  • jaundice (yellowing of the skin or eyes); or
  • fever, chills, sore throat, swollen tongue, joint pain, cough, feeling short of breath.

Less serious side effects may include:

  • mild stomach pain, feeling full;
  • slight hair loss;
  • headache;
  • muscle weakness;
  • depression, nervousness;
  • ringing in your ears; or
  • sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Fansidar (Sulfadoxine and Pyrimethamine)

What is Patient Information Overview?

A concise overview of the drug for the patient or caregiver from First DataBank.

Fansidar Overview - Patient Information: Side Effects

SIDE EFFECTS: Consult your pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Read the entire patient information overview for Fansidar (Sulfadoxine and Pyrimethamine)

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Fansidar FDA Prescribing Information: Side Effects
(Adverse Reactions)


For completeness, all major reactions to sulfonamides and to pyrimethamine are included below, even though they may not have been reported with Fansidar (see WARNINGS and PRECAUTIONS: Information For The Patient).

Hematological Changes

Agranulocytosis, aplastic anemia, megaloblastic anemia, thrombocytopenia, leukopenia, hemolytic anemia, purpura, hypoprothrombinemia, methemoglobinemia, and eosinophilia.

Skin and Miscellaneous Sites Allergic Reactions

Erythema multiforme, Stevens-Johnson syndrome, generalized skin eruptions, toxic epidermal necrolysis, urticaria, serum sickness, pruritus, exfoliative dermatitis, anaphylactoid reactions, periorbital edema, conjunctival and scleral injection, photosensitization, arthralgia, allergic myocarditis, slight hair loss, Lyell's syndrome,

Gastrointestinal Reactions

Glossitis, stomatitis, nausea, emesis, abdominal pains, hepatitis, hepatocellular necrosis, diarrhea, pancreatitis, feeling of fullness, and transient rise of liver enzymes.

Central Nervous System Reactions

Headache, peripheral neuritis, mental depression, convulsions, ataxia, hallucinations, tinnitus, vertigo, insomnia, apathy, fatigue, muscle weakness, nervousness, and polyneuritis.

Respiratory Reactions

Pulmonary infiltrates resembling eosinophilic or allergic alveolitis.


Renal failure, interstitial nephritis, BUN and serum creatinine elevation, toxic nephrosis with oliguria and anuria, and crystalluria.

Miscellaneous Reactions

Drug fever, chills, periarteritis nodosa and LE phenomenon have occurred.

The sulfonamides bear certain chemical similarities to some goitrogens, diuretics (acetazolamide and the thiazides), and oral hypoglycemic agents. Diuresis and hypoglycemia have occurred rarely in patients receiving sulfonamides. Cross-sensitivity may exist with these agents. Rats appear to be especially susceptible to the goitrogenic effects of sulfonamides, and long-term administration has produced thyroid malignancies in the species.

Read the entire FDA prescribing information for Fansidar (Sulfadoxine and Pyrimethamine)

Fansidar - User Reviews

Fansidar User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Fansidar sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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