Fareston (Toremifene) Drug Information: Overdosage and Contraindications

Pill Identifier Search

May 27, 2012

Fareston

Breast Cancer »

Breast cancer facts

Breast cancer is the most common cancer among American women.
One in every eight women in the United States develops breast cancer.
There are many types of breast cancer that differ in their capability of spreading (metastasize) to other body tissues.
The causes of breast cancer are not yet fully known although a number of risk factors have been identified.
There are many different types of breast cancer.
Breast cancer is diagnosed with physician and self-examination of the breasts, mammography, ultrasound testing, and biopsy.
Treatment of breast cancer depends on the type of cancer and its stage (the extent of spread in the body).

According to the American Cancer society:

Over 200,000 new cases of invasive breast cancer are diagnosed each year.
Nearly 40,000 women will die of breast cancer in 2011.
There are over 2...

Read the Breast Cancer article »

« Previous
1
2
3
4
5
6
7
8
9
10
11
12
13
Next »

Fareston User Reviews >>

Fareston

Breast Cancer Slideshow Pictures

Take the Breast Cancer Quiz

Disease Prevention in Women Slideshow Pictures

font size

OVERDOSE

Lethality was observed in rats following single oral doses that were ≥ 1000 mg/kg (about 150 times the recommended human dose on a mg/m² basis) and was associated with gastric atony/dilatation leading to interference with digestion and adrenal enlargement.

Vertigo, headache, and dizziness were observed in healthy volunteer studies at a daily dose of 680 mg for 5 days. The symptoms occurred in two of the five subjects during the third day of the treatment and disappeared within 2 days of discontinuation of the drug. No immediate concomitant changes in any measured clinical chemistry parameters were found. In a study in postmenopausal breast cancer patients, toremifene 400 mg/m²/day caused dose-limiting nausea, vomiting, and dizziness, as well as reversible hallucinations and ataxia in one patient.

Theoretically, overdose may be manifested as an increase of antiestrogenic effects, such as hot flashes; estrogenic effects, such as vaginal bleeding; or nervous system disorders, such as vertigo, dizziness, ataxia, and nausea. There is no specific antidote and the treatment is symptomatic.

CONTRAINDICATIONS

Hypersensitivity to the Drug

FARESTON is contraindicated in patients with known hypersensitivity to the drug.

QT Prolongation, Hypokalemia, Hypomagnesemia

Toremifene should not be prescribed to patients with congenital/acquired QT prolongation (long QT syndrome), uncorrected hypokalemia, or uncorrected hypomagnesemia.

Last reviewed on RxList: 6/3/2011
This monograph has been modified to include the generic and brand name in many instances.