Serious ill effects have not been reported following acute ingestion of large doses of oral contraceptives by young children. Overdosage may cause nausea, and withdrawal bleeding may occur in females.

Noncontraceptive Health Benefits

The following noncontraceptive health benefits related to the use of oral contraceptives are supported by epidemiological studies which largely utilized oral-contraceptive formulations containing doses exceeding 0.035 mg of ethinyl estradiol or 0.05 mg of mestranol. Effects on menses:

• Increased menstrual cycle regularity
• Decreased blood loss and decreased incidence of iron-deficiency anemia
• Decreased incidence of dysmenorrhea

Effects related to inhibition of ovulation:

• Decreased incidence of functional ovarian cysts
• Decreased incidence of ectopic pregnancies

Effects from long-term use:

• Decreased incidence of fibroadenomas and fibrocystic disease of the breast
• Decreased incidence of acute pelvic inflammatory disease
• Decreased incidence of endometrial cancer
• Decreased incidence of ovarian cancer

Combination oral contraceptives should not be used in women who currently have the following conditions:

•  Thrombophlebitis or thromboembolic disorders
•  History of deep vein thrombophlebitis or thromboembolic disorders
•  Cerebrovascular or coronary artery disease (current or history)
•  Valvular heart disease with thrombogenic complications
•  Uncontrolled hypertension
•  Diabetes with vascular involvement
•  Headaches with focal neurological symptoms, such as aura
•  Major surgery with prolonged immobilization
•  Known or suspected carcinoma of the breast or personal history of breast cancer
•  Carcinoma of the endometrium or other known or suspected estrogen-dependent neoplasia
•  Undiagnosed abnormal genital bleeding
•  Cholestatic jaundice of pregnancy or jaundice with prior pill use
•  Hepatic adenomas or carcinomas, or active liver disease
•  Known or suspected pregnancy
•  Hypersensitivity to any component of this product

Last reviewed on RxList: 1/29/2008
This monograph has been modified to include the generic and brand name in many instances.