In this Article

• What is estradiol vaginal (systemic) (Femring)?
• What are the possible side effects of estradiol vaginal (systemic) (Femring)?
• What is the most important information I should know about estradiol vaginal (systemic) (Femring)?
• What should I discuss with my health care provider before using estradiol vaginal (systemic) (Femring)?
• How should I use estradiol vaginal (systemic) (Femring)?
• What happens if I miss a dose (Femring)?
• What happens if I overdose (Femring)?
• What should I avoid while using estradiol vaginal (systemic) (Femring)?
• What other drugs will affect estradiol vaginal (systemic) (Femring)?
• Where can I get more information?

What happens if I miss a dose (Femring)?

Remove the vaginal ring and insert a new one as soon as you remember. Do not use an extra vaginal ring to make up the missed wearing time.

If a vaginal ring falls out, rinse it with warm water and reinsert it. If it slides down into the lower part of the vagina, use your finger to push it in farther.

What happens if I overdose (Femring)?

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include breast tenderness, drowsiness, dizziness, nausea, vomiting, stomach pain, or vaginal bleeding.

What should I avoid while using estradiol vaginal (systemic) (Femring)?

Avoid using other vaginal products without your doctor's advice.

What other drugs will affect estradiol vaginal (systemic) (Femring)?

Before using estradiol vaginal, tell your doctor if you are using any of the following drugs:

• St. John's wort;
• carbamazepine (Carbatrol, Tegretol)or phenobarbital (Luminal, Solfoton);
• a blood thinner such as warfarin (Coumadin);
• ritonavir (Norvir);
• rifampin (Rifadin, Rifater, Rifamate, Rimactane);
• thyroid replacement medication such as levothyroxine (Synthroid) and others;
• an antibiotic such as clarithromycin (Biaxin) or erythromycin (E-Mycin, E.E.S., Erythrocin, Ery-Tab); or
• an antifungal medication such as ketoconazole (Nizoral) or itraconazole (Sporanox).

This list is not complete and there may be other drugs that can interact with estradiol vaginal. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about estradiol vaginal (systemic).

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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