April 29, 2017
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Fenofibrate

Medical and Pharmacy Editor:

Brand Name: Tricor, Lofibra tablets, Fenoglide, Lipofen, Triglide

Generic Name: fenofibrate

Drug Class: Fibric Acid Agents

What Is Fenofibrate and How Does It Work?

Fenofibrate is used along with a proper diet to help lower "bad" cholesterol and fats (such as LDL, triglycerides) and raise "good" cholesterol (HDL) in the blood. It works by increasing the natural substance (enzyme) that breaks down fats in the blood. Fenofibrate belongs to a group of drugs known as "fibrates." Lowering triglycerides in people with very high triglyceride blood levels may decrease the risk of pancreas disease (pancreatitis). However, fenofibrate might not lower your risk of a heart attack or stroke. Talk to your doctor about the risks and benefits of fenofibrate.

In addition to eating a proper diet (such as a low-cholesterol/low-fat diet), other lifestyle changes that may help fenofibrate work better include exercising, losing weight if overweight, and stopping smoking. Consult your doctor for more details.

Fenofibrate is available under the following different brand names: Tricor, Lofibra tablets, Fenoglide, Lipofen, and Triglide.

Dosages of Fenofibrate:

Dosage Forms and Strengths

TriCor tablet

  • 48 mg
  • 145 mg

Lofibra tablet

  • 54 mg
  • 160 mg

Fenoglide tablet

  • 40 mg
  • 120 mg

Triglide tablet

  • 160 mg

Lipofen capsule

  • 50 mg
  • 150 mg

Dosage Considerations – Should be Given as Follows:

Pediatric: Safety and efficacy not established

TriCor

  • Hypercholesterolemia, mixed dyslipidemia: Initially, 145 mg orally once/day
  • Hypertriglyceridemia: Initially, 48-145 mg orally once/day
  • Titrate every 4-8 weeks up to no more than 145 mg orally once/day
  • Geriatric, initial: 48 mg/day; evaluate before increase dose

Triglide

  • Hypercholesterolemia, Mixed Dyslipidemia: initial 160 mg orally once/day
  • Hypertriglyceridemia: 50-160 mg orally once/day initially
  • Geriatric, initial: 50 mg/day

Lipofen

  • Hypercholesterolemia, Mixed Dyslipidemia: initial 150 mg orally once/day
  • Hypertriglyceridemia: initial 50-150 mg orally once/day
  • Geriatric, initial: No more than 50 mg/day

Lofibra tablets

  • Hypercholesterolemia, Mixed Dyslipidemia: 160 mg orally once/day
  • Hypertriglyceridemia: 54-160 mg orally once/day
  • Geriatric, initial: 54 mg/day

Fenoglide

  • Hypercholesterolemia, Mixed Dyslipidemia: 120 mg orally once/day
  • Hypertriglyceridemia: 40-120 mg orally once/day
  • Geriatric, initial: 40 mg/day

Dosage Considerations

Overdose management

  • Symptoms include GI distress
  • Treatment is supportive

Dosing Modifications

Renal impairment (CrCl less than 50 mL/min):

  • TriCor: Initial, 48 mg/day initially; evaluate before increase dose
  • Triglide: Initial, 50 mg/day
  • Lipofen: Initial, no more than 50 mg/day
  • Lofibra tablets: Initial, 54 mg/day
  • Fenoglide: Initial, 40 mg/day

Administration

  • TriCor, Triglide, and Lofibra tablets can be taken without regard to meals
  • Lipofen: Take with meals
Medically Reviewed by a Doctor on 4/14/2017




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