Feraheme (Ferumoxytol Injection) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 10, 2012

Feraheme

Hypertensive Kidney Disease »

Introduction to high blood pressure and kidney disease

The kidneys play a key role in keeping a person's blood pressure in a healthy range, and blood pressure, in turn, can affect the health of the kidneys. High blood pressure, also called hypertension, can damage the kidneys and lead to chronic kidney disease (CKD).

What is high blood pressure?

Blood pressure measures the force of blood against the walls of the blood vessels. Extra fluid in the body increases the amount of fluid in blood vessels and makes blood pressure higher. Narrow, stiff, or clogged blood vessels also raise blood pressure.

Hypertension can result from too much fluid in normal blood vessels or from normal fluid in narrow, stiff, or clogged blood vessels.

People with high blood pressure should see their doctor regularly.

How does high blood pressure hurt...

Read the Hypertensive Kidney Disease article »

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Feraheme

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Feraheme®
(ferumoxytol) Injection For Intravenous (IV) use

DRUG DESCRIPTION

Feraheme, an iron replacement product, is a non-stoichiometric magnetite (superparamagnetic iron oxide) coated with polyglucose sorbitol carboxymethylether. The overall colloidal particle size is 17-31 nm in diameter. The chemical formula of Feraheme is Fe₅₈₇₄O₈₇₅₂-C₁₁₇₁₉H₁₈₆₈₂O₉₉₃₃Na₄₁₄ with an apparent molecular weight of 750 kDa.

Feraheme injection is an aqueous colloidal product that is formulated with mannitol. It is a black to reddish brown liquid, and is provided in single use vials containing 510 mg of elemental iron. Each mL of the sterile colloidal solution of Feraheme injection contains 30 mg of elemental iron and 44 mg of mannitol, and has low bleomycin-detectable iron. The formulation is isotonic with an osmolality of 270-330 mOsm/kg. The product contains no preservatives, and has a pH of 6 to 8.

What are the possible side effects of ferumoxytol (Feraheme)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; wheezing or difficult breathing; swelling of your face, lips, tongue, or throat.

Watch for signs of allergic reaction for at least 30 minutes after your injection.

Call your doctor if you have serious side effects such as:

feeling like you might pass out;
easy bruising;
swelling where the medicine was injected; or
worsening symptoms of kidney failure (urinating less than usual or not at all,...

Read All Potential Side Effects and See Pictures of Feraheme »

What are the precautions when taking ferumoxytol injection (Feraheme)?

Before taking ferumoxytol, tell your doctor or pharmacist if you are allergic to it; or if you have had a reaction to other types of injectable iron; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

During use and for 3 months after your last injection, tell X-ray staff that you use or used this medication. This medication can interfere with the results of an MRI...

Read All Potential Precautions of Feraheme »

Last reviewed on RxList: 8/5/2011
This monograph has been modified to include the generic and brand name in many instances.