Overdose with Feridex I.V. (ferumoxides injectable solution) has not been reported. Acute toxicity is apt to be related to iron overload, acute back pain and allergic events. Chronic administration of therapeutic iron dextran in excess of the total amount of iron needed for iron stores may lead to hemosiderosis.
A study of (59Fe) complexed iron-dextran utilizing isotonic saline in a 4-hour in vitro dialysis run indicated that less than 0.5% of the injected radio labeled iron dextran traversed the dialysis membrane. Feridex I.V. contains iron associated with dextran. Whether Feridex I.V. (ferumoxides injectable solution) is dialyzable is not known.
Feridex I.V. (ferumoxides injectable solution) is contraindicated in patients with known allergic or hypersensitivity reactions to parenteral iron, parenteral dextran, parenteral iron-dextran, or parenteral iron-polysaccharide preparations.
Last reviewed on RxList: 12/2/2009
This monograph has been modified to include the generic and brand name in many instances.
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