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To reduce the development of drug-resistant bacteria and maintain the effectiveness of Flagyl (metronidazole) and other antibacterial drugs, Flagyl (metronidazole) should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.
Metronidazole has been shown to be carcinogenic in mice and rats. (See PRECAUTIONS.) Unnecessary use of the drug should be avoided. Its use should be reserved for the conditions described in the INDICATIONS section below.
Flagyl (metronidazole) is an oral synthetic antiprotozoal and antibacterial agent, l-β-hydroxyethyl)-2-methyl-5-nitroimidazole, which has the following structural formula:
Flagyl tablets contain 250 mg or 500 mg of metronidazole. Inactive ingredients include cellulose, FD&C Blue No. 2 Lake, hydroxypropyl cellulose, hypromellose, polyethylene glycol, stearic acid, and titanium dioxide.
What are the possible side effects of metronidazole (Flagyl, Flagyl 375, Flagyl ER)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
- numbness or tingling in your hands or feet;
- white patches or sores inside your mouth or on your lips;
- pain or burning when you urinate;
- diarrhea that is watery or bloody;
- vision problems, pain behind your eyes;
- trouble concentrating, slurred speech, mood or behavior changes,...
What are the precautions when taking metronidazole (Flagyl)?
Before taking metronidazole, tell your doctor or pharmacist if you are allergic to it; or to other nitroimidazoles such as tinidazole; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver problems, nervous system disorders (e.g., seizures), blood disorders, Crohn's disease.
Avoid alcoholic beverages while taking this medication and for at least 1 day (3 days if you are taking the oral capsules) after finishing this medicine because drinking alcohol may result in severe stomach upset/cramps, nausea, vomiting, headache and flushing.
Last reviewed on RxList: 1/31/2011
This monograph has been modified to include the generic and brand name in many instances.
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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