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Single oral doses of metronidazole, up to 15 g, have been reported in suicide attempts and accidental overdoses. Symptoms reported include nausea, vomiting, and ataxia.
Oral metronidazole has been studied as a radiation sensitizer in the treatment of malignant tumors. Neurotoxic effects, including seizures and peripheral neuropathy, have been reported after 5 to 7 days of doses of 6 to 10.4 g every other day.
Treatment: There is no specific antidote for Flagyl (metronidazole) overdose; therefore, management of the patient should consist of symptomatic and supportive therapy.
Flagyl (metronidazole) is contraindicated in patients with a prior history of hypersensitivity to metronidazole or other nitroimidazole derivatives.
In patients with trichomoniasis, Flagyl (metronidazole) is contraindicated during the first trimester of pregnancy. (See WARNINGS)
Last reviewed on RxList: 1/31/2011
This monograph has been modified to include the generic and brand name in many instances.
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