Flagyl Injection (Metronidazole Injection) Drug Information: Overdosage and Contraindications

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May 27, 2012

Flagyl Injection

Giardia Lamblia »

What is giardiasis?

Giardiasis (gee-ar-die-a-sis with a soft "G") is an infection of the small intestine that is caused by the parasite, Giardia intestinalis, also known as Giardia lamblia. It is the most common cause of parasitic gastrointestinal disease; it is estimated that up to 2.5 million cases of giardiasis occur each year in the U.S., and up to 20% of the world's population is chronically infected.

Giardia lamblia exists in two forms, an active form called a trophozoite, and an inactive form called a cyst. The active trophozoite attaches to the lining of the small intestine with a "sucker" and is responsible for causing the signs and symptoms of giardiasis. The trophozoite cannot live long outside of the body, therefore it cannot spread the infection to others. The inactive cyst, on the other hand, can exist for prolonged periods outside the body. When it is ingested, stomach acid activates the cyst, and the cyst develops in...

Read the Giardia Lamblia article »

Flagyl Injection

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OVERDOSE

Use of dosages of intravenous metronidazole higher than those recommended has been reported. These include the use of 27 mg/kg three times a day for 20 days, and the use of 75 mg/kg as a single loading dose followed by 7.5 mg/kg maintenance doses. No adverse reactions were reported in either of the two cases.

Single oral dose of metronidazole, up to 15 g, have been reported in suicide attempts and accidental overdoses. Symptoms reported included nausea, vomiting and ataxia.

Oral metronidazole has been studied as a radiation sensitizer in the treatment of malignant tumors. Neurotoxic effects, including seizures and peripheral neuropathy, have been reported after 5 to 7 days of doses of 6 to 10.4 g every other day.

Treatment: There is no specific antidote for overdose; therefore, management of the patient should consist of symptomatic and supportive therapy.

CONTRAINDICATIONS

Metronidazole Injection, USP RTU® is contraindicated in patients with a prior history of hypersensitivity to metronidazole or other nitroimidazole derivatives.

Last reviewed on RxList: 6/22/2009
This monograph has been modified to include the generic and brand name in many instances.