Flexeril (Cyclobenzaprine Hcl) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

Flexeril

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What is whiplash?

Whiplash is a relatively common injury that occurs to a person's neck following a sudden acceleration-deceleration force, most commonly from motor vehicle accidents. The term "whiplash" was first used in 1928. The term "railway spine" was used to describe a similar condition that was common in persons involved in train accidents prior to 1928. The term "whiplash injury" describes damage to both the bone structures and soft tissues, while "whiplash associated disorders" describes a more severe and chronic condition.

Fortunately, whiplash is typically not a life threatening injury, but it can lead to a prolonged period of partial disability. There are significant economic expenses related to whiplash that can reach 30 billion dollars a year in the United States, including:

medical care,
disability,
sick leave,
lost productivity, and

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FLEXERIL
(cyclobenzaprine hydrochloride) Tablet, Film Coated

DRUG DESCRIPTION

Cyclobenzaprine hydrochloride is a white, crystalline tricyclic amine salt with the empirical formula C₂₀H₂₁N•HCl and a molecular weight of 311.9. It has a melting point of 217#C, and a pKa of 8.47 at 25#C. It is freely soluble in water and alcohol, sparingly soluble in isopropanol, and insoluble in hydrocarbon solvents. If aqueous solutions are made alkaline, the free base separates. Cyclobenzaprine HCl is designated chemically as 3-(5H -dibenzo[a,d] cyclohepten-5-ylidene)-N, N-dimethyl-1-propanamine hydrochloride, and has the following structural formula:

FLEXERIL (cyclobenzaprine hydrochloride) Structural Formula Illustration

FLEXERIL 5 mg (Cyclobenzaprine HCl) is supplied as a 5 mg tablet for oral administration. FLEXERIL 10 mg (Cyclobenzaprine HCl) is supplied as a 10 mg tablet for oral administration.

FLEXERIL 5 mg (Cyclobenzaprine HCl) tablets contain the following inactive ingredients: hydroxypropyl cellulose, hypromellose, lactose, magnesium stearate, starch, titanium dioxide, Yellow D&C #10 Aluminum Lake HT, and Yellow FD&C #6 Aluminum Lake.

FLEXERIL 10 mg (Cyclobenzaprine HCl) tablets contain the following inactive ingredients: hydroxypropyl cellulose, hypromellose, iron oxide, lactose, magnesium stearate, starch, and titanium dioxide.

What are the possible side effects of cyclobenzaprine (Amrix, Comfort Pac with Cyclobenzaprine, Fexmid, Flexeril)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using cyclobenzaprine and call your doctor at once if you have any of these serious side effects:

fast, pounding, or uneven heartbeats;
chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
sudden numbness or weakness, especially on one...

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What are the precautions when taking cyclobenzaprine hcl (Flexeril)?

Before taking cyclobenzaprine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: overactive thyroid (hyperthyroidism), irregular heartbeats (arrhythmia), other heart problems (congestive heart failure, heart block or conduction disorders), recent heart attack, moderate or severe liver disease.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: severe difficulty urinating (urinary retention),...

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Last reviewed on RxList: 4/13/2011
This monograph has been modified to include the generic and brand name in many instances.