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Florinef Drug Center

Florinef (fludrocortisone) Acetate is used to treat conditions in which the body does not produce enough of its own steroids, such as Addison's disease, and salt-losing adrenogenital syndrome. It is a steroid. The brand name Florinef is discontinued in the U.S. It is available in generic form. Common side effects include stomach upset, headache, and menstrual changes (e.g., delayed/irregular/absent periods).

Dosage of fludrocortisone depends on the severity of the disease and patient's response. To treat Addison's disease, the usual dose is 0.1 mg daily. The recommended dosage for treating the salt-losing adrenogenital syndrome is 0.1 mg to 0.2 mg daily. Fludrocortisone may interact with aspirin, amphotericin B, diuretics (water pills), digoxin, phenytoin, rifampin, birth control pills or hormone replacement therapy, blood thinners, insulin or oral diabetes medications, steroids, or barbiturates. Tell your doctor all medications you use. During pregnancy, fludrocortisone should be used only when prescribed. Infants born to mothers who have used this medication may have low levels of corticosteroid hormone. Tell your doctor if you notice persistent nausea/vomiting, severe diarrhea, or weakness in your newborn. This medication passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

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