FLOVENT® DISKUS® 50 mcg
(fluticasone propionate) Inhalation Powder, 50 mcg
FLOVENT® DISKUS® 100 mcg
(fluticasone propionate) Inhalation Powder, 100 mcg
FLOVENT® DISKUS® 250 mcg
(fluticasone propionate) Inhalation Powder, 250 mcg
The active component of FLOVENT DISKUS (fluticasone propionate) 50 mcg, FLOVENT DISKUS 100 mcg, and FLOVENT DISKUS 250 mcg is fluticasone propionate, a corticosteroid having the chemical name S-(fluoromethyl) 6α,9-difluoro-11β,17-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioate, 17-propionate and the following chemical structure:
Fluticasone propionate is a white powder with a molecular weight of 500.6, and the empirical formula is C25H31F3O5S. It is practically insoluble in water, freely soluble in dimethyl sulfoxide and dimethylformamide, and slightly soluble in methanol and 95% ethanol.
FLOVENT DISKUS (fluticasone propionate) 50 mcg, FLOVENT DISKUS (fluticasone propionate) 100 mcg, and FLOVENT DISKUS (fluticasone propionate) 250 mcg are specially designed plastic inhalation delivery systems containing a double-foil blister strip of a powder formulation of fluticasone propionate intended for oral inhalation only. The DISKUS® inhalation unit, which is the delivery component, is an integral part of the drug product. Each blister on the double-foil strip within the unit contains 50, 100, or 250 mcg of microfine fluticasone propionate in 12.5 mg of formulation containing lactose (which contains milk proteins). After a blister containing medication is opened by activating the DISKUS, the medication is dispersed into the airstream created by the patient inhaling through the mouthpiece.
Under standardized in vitro test conditions, FLOVENT DISKUS delivers 46, 94, or 229 mcg of fluticasone propionate from FLOVENT DISKUS (fluticasone propionate) 50 mcg, FLOVENT DISKUS 100 mcg, or FLOVENT DISKUS (fluticasone propionate) 250 mcg, respectively, when tested at a flow rate of 60 L/min for 2 seconds. In adult patients with obstructive lung disease and severely compromised lung function (mean forced expiratory volume in 1 second [FEV1] 20% to 30% of predicted), mean peak inspiratory flow (PIF) through a DISKUS was 82.4 L/min (range, 46.1 to 115.3 L/min). In children with asthma 4 and 8 years old, mean PIF through FLOVENT DISKUS (fluticasone propionate) was 70 and 104 L/min, respectively (range, 48 to 123 L/min).
The actual amount of drug delivered to the lung may depend on patient factors, such as inspiratory flow profile.
What are the possible side effects of fluticasone inhalation (Flovent Diskus, Flovent HFA)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using fluticasone and call your doctor at once if you have a serious side effect such as:
- weakness, tired feeling, nausea, vomiting, feeling like you might pass out;
- skin rash, bruising, severe tingling, numbness, pain, muscle weakness;
- blurred vision, eye pain, or seeing halos around lights;
- signs of infection such as fever, chills, sore throat, ear...
What are the precautions when taking fluticasone propionate (Flovent Diskus)?
Before using fluticasone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as lactose, milk proteins), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: current/past infections (such as tuberculosis, herpes), certain eye problems (cataracts, glaucoma, herpes infection of the eye), bone loss (osteoporosis), liver disease.
This medication may mask signs of infection. It can make you more likely to get infections or may worsen any current infections. Therefore, wash your hands well to prevent the spread of infection. Avoid contact with...
Last reviewed on RxList: 4/27/2009
This monograph has been modified to include the generic and brand name in many instances.
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