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Chronic overdosage may result in signs/symptoms of hypercorticism (see PRECAUTIONS: General). Inhalation by healthy volunteers of a single dose of 4,000 mcg of fluticasone propionate inhalation powder or single doses of 1,760 or 3,520 mcg of fluticasone propionate inhalation aerosol was well tolerated. Doses of 1,320 mcg administered to healthy human volunteers twice daily for 7 to 15 days were also well tolerated. Repeat oral doses up to 80 mg daily for 10 days in healthy volunteers and repeat oral doses up to 20 mg daily for 42 days in patients were well tolerated. Adverse reactions were of mild or moderate severity, and incidences were similar in active and placebo treatment groups. The oral and subcutaneous median lethal doses in mice and rats were > 1,000 mg/kg ( > 2,000 and > 4,100 times, respectively, the maximum recommended daily inhalation dose in adults and > 9,600 and > 20,000 times, respectively, the maximum recommended daily inhalation dose in children on a mg/m2 basis).
Last reviewed on RxList: 4/27/2009
This monograph has been modified to include the generic and brand name in many instances.
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