August 24, 2016
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Flovent HFA

"NEW YORK (Reuters Health) - New research in mice and human lung tissue suggests soluble ADAM33 (sADAM33) may prompt airway remodeling and boost allergic airway inflammation, making it a possible therapeutic target.

As Dr. Hans Michael"...

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Flovent HFA

FLOVENT HFA- fluticasone propionate aerosol, metered




DRUG DESCRIPTION

The active component of FLOVENT HFA 44 mcg Inhalation Aerosol, FLOVENT HFA 110 mcg Inhalation Aerosol, and FLOVENT HFA 220 mcg Inhalation Aerosol is fluticasone propionate, a corticosteroid having the chemical name S-(fluoromethyl) 6α,9-difluoro-11β,17-dihydroxy-16α-methyl- 3-oxoandrosta-1,4-diene-17β-carbothioate, 17-propionate and the following chemical structure:

Fluticasone propionate - Structural Formula Illustration

Fluticasone propionate is a white powder with a molecular weight of 500.6, and the empirical formula is C25H31F3O5S. It is practically insoluble in water, freely soluble in dimethyl sulfoxide and dimethylformamide, and slightly soluble in methanol and 95% ethanol.

Flovent HFA is a dark orange plastic inhaler with a peach strapcap containing a pressurized metereddose aerosol canister fitted with a counter. Each canister contains a microcrystalline suspension of micronized fluticasone propionate in propellant HFA-134a (1,1,1,2-tetrafluoroethane). It contains no other excipients.

After priming, each actuation of the inhaler delivers 50, 125, or 250 mcg of fluticasone propionate in 60 mg of suspension (for the 44-mcg product) or in 75 mg of suspension (for the 110- and 220-mcg products) from the valve. Each actuation delivers 44, 110, or 220 mcg of fluticasone propionate from the actuator. The actual amount of drug delivered to the lung will depend on patient factors, such as the coordination between the actuation of the inhaler and inspiration through the delivery system.

Prime FLOVENT HFA before using for the first time by releasing 4 sprays into the air away from the face, shaking well for 5 seconds before each spray. In cases where the inhaler has not been used for more than 7 days or when it has been dropped, prime the inhaler again by shaking well for 5 seconds and releasing 1 spray into the air away from the face.

What are the possible side effects of fluticasone inhalation (Flovent Diskus, Flovent HFA)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using fluticasone and call your doctor at once if you have a serious side effect such as:

  • weakness, tired feeling, nausea, vomiting, feeling like you might pass out;
  • skin rash, bruising, severe tingling, numbness, pain, muscle weakness;
  • blurred vision, eye pain, or seeing halos around lights;
  • signs of infection such as fever, chills, sore throat, ear...

Read All Potential Side Effects and See Pictures of Flovent HFA »

What are the precautions when taking fluticasone propionate hfa (Flovent HFA)?

Before using fluticasone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: current/past infections (such as tuberculosis, herpes), certain eye problems (cataracts, glaucoma, herpes infection of the eye), bone loss (osteoporosis), liver disease.

This medication may mask signs of infection. It can make you more likely to get infections or may worsen any current infections. Therefore, wash your hands well to prevent the spread of infection. Avoid contact with people who have infections that may...

Read All Potential Precautions of Flovent HFA »

Last reviewed on RxList: 7/26/2016
This monograph has been modified to include the generic and brand name in many instances.

Flovent HFA - User Reviews

Flovent HFA User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Flovent HFA sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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