"Immunoscore â€” a scoring system to determine specific lymphocyte populations in the core of the tumor and at its invasive margins â€” is emerging as a prognostic marker in colorectal cancer (CRC), according to researchers.
A new study sh"...
When floxuridine is given by rapid intra-arterial injection it is apparently rapidly catabolized to 5- fluorouracil. Thus, rapid injection of floxuridine produces the same toxic and antimetabolic effects as does 5-fluorouracil. The primary effect is to interfere with the synthesis of deoxyribonucleic acid (DNA) and to a lesser extent inhibit the formation of ribonucleic acid (RNA). However, when floxuridine is given by continuous intra-arterial infusion its direct anabolism to floxuridinemonophosphate is enhanced, thus increasing the inhibition of DNA.
Floxuridine is metabolized in the liver. The drug is excreted intact and as urea, fluorouracil, α-fluoro- β-ureidopropionic acid, dihydrofluorouracil, α-fluoro-β-guanidopropionic acid and α-fluoro-β-alanine in the urine; it is also expired as respiratory carbon dioxide. Pharmacokinetic data on intra-arterial infusion of floxuridine are not available.
Last reviewed on RxList: 11/29/2016
This monograph has been modified to include the generic and brand name in many instances.
Additional Floxuridine Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Get the latest treatment options.