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floxuridine

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Floxuridine

Overdosage
Contraindications

OVERDOSE

The possibility of overdosage with floxuridine is unlikely in view of the mode of administration. Nevertheless, the anticipated manifestations would be nausea, vomiting, diarrhea, gastrointestinal ulceration and bleeding, bone marrow depression (including thrombocytopenia, leukopenia and agranulocytosis). No specific antidotal therapy exists. Patients who have been exposed to an overdosage of floxuridine should be monitored hematologically for at least 4 weeks. Should abnormalities appear, appropriate therapy should be utilized.

The acute intravenous toxicity of floxuridine is as follows:

Species LD50
(mg/kg ± S.E.)
Mouse 880 ± 51
Rat 670 ± 73
Rabbit 94 ± 19.6
Dog 157 ± 46

CONTRAINDICATIONS

Floxuridine therapy is contraindicated for patients in a poor nutritional state, those with depressed bone marrow function or those with potentially serious infections.

Last reviewed on RxList: 11/13/2008
This monograph has been modified to include the generic and brand name in many instances.

Overdosage
Contraindications
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