Floxuridine (Floxuridine) Drug Information: Overdosage and Contraindications

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May 27, 2012

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Floxuridine

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OVERDOSE

The possibility of overdosage with floxuridine is unlikely in view of the mode of administration. Nevertheless, the anticipated manifestations would be nausea, vomiting, diarrhea, gastrointestinal ulceration and bleeding, bone marrow depression (including thrombocytopenia, leukopenia and agranulocytosis). No specific antidotal therapy exists. Patients who have been exposed to an overdosage of floxuridine should be monitored hematologically for at least 4 weeks. Should abnormalities appear, appropriate therapy should be utilized.

The acute intravenous toxicity of floxuridine is as follows:

Species	LD₅₀ (mg/kg ± S.E.)
Mouse	880 ± 51
Rat	670 ± 73
Rabbit	94 ± 19.6
Dog	157 ± 46

CONTRAINDICATIONS

Floxuridine therapy is contraindicated for patients in a poor nutritional state, those with depressed bone marrow function or those with potentially serious infections.

Last reviewed on RxList: 11/13/2008
This monograph has been modified to include the generic and brand name in many instances.