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floxuridine Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Floxuridine for Injection is a cancer (antineoplastic) medication used in the treatment of digestive system cancers that have spread to the liver. This medication is available in generic form. Common side effects include nausea and vomiting (may be severe), mild diarrhea, loss of appetite, tiredness, redness at the injection site, or dry skin.
The recommended therapeutic dosage schedule of floxuridine by continuous arterial infusion is 0.1 to 0.6 mg/kg/day. Floxuridine may interact with "live" vaccines. Tell your doctor all medications and supplements you use and all vaccines you recently received. Floxuridine is not recommended for use during pregnancy. It may harm a fetus. Consult your doctor to discuss birth control. It is recommended that men and women use 2 forms of birth control (e.g., condoms, birth control pills) while using this medication. It is unknown if this drug passes into breast milk. Because of the possible risk to the infant, breastfeeding while using floxuridine is not recommended.
Our Floxuridine for Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
floxuridine in Detail - Patient Information: Side Effects
If you experience any of the following serious side effects from floxuridine, contact your doctor immediately:
- an allergic reaction (including difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
- decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; or fever, chills, or signs of infection);
- severe vomiting;
- diarrhea, frequent bowel movements or watery stools; or
- sores in the mouth or throat; or
- stomach pain or heartburn or black, bloody or tarry stools.
Other, less serious side effects may be more likely to occur. Continue taking floxuridine and talk to your doctor if you experience:
- mild to moderate nausea, vomiting or loss of appetite;
- redness of the palms of the hands or soles of the feet;
- increased eye watering;
- balance problems;
- rash and itching; or
- temporary hair loss.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for floxuridine (Floxuridine)
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
floxuridine Overview - Patient Information: Side Effects
Temporary hair loss may occur. Normal hair growth should return after treatment has ended.
Many people using this medication have some serious side effects. However, your doctor has prescribed this drug because he or she has judged that the benefit to you is greater than the risk of side effects.
This medication can lower the body's ability to fight an infection. Tell your doctor promptly if you develop any signs of an infection such as fever or chills.
Tell your doctor right away if you have any serious side effects, including: mouth sores, sore throat, painful/difficult swallowing, persistent or severe vomiting/diarrhea, easy or unusual bruising/bleeding, black stools, blood/mucus in the stools, vomit that looks like coffee grounds, cramps/pain in the stomach/abdomen, yellowing eyes/skin, dark urine, weakness, weight loss, skin problems (e.g., unusual sunburn, peeling/darkening of the skin), muscle/joint pain.
Get medical help right away if any of these rare but very serious side effects occur: chest/jaw/left arm pain, warmth/swelling/pain/leaking at the injection site, pain/swelling/redness/weakness of the arms or legs, calf pain/swelling that is warm to the touch, shortness of breath, coughing up blood, sudden vision changes, weakness on one side of the body, severe clumsiness/trouble walking, slurred speech, confusion, severe headache.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for floxuridine (Floxuridine)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
floxuridine FDA Prescribing Information: Side Effects
Adverse reactions to the arterial infusion of floxuridine are generally related to the procedural complications of regional arterial infusion.
The more common adverse reactions to the drug are nausea, vomiting, diarrhea, enteritis, stomatitis and localized erythema. The more common laboratory abnormalities are anemia, leukopenia, thrombo-cytopenia and elevations of alkaline phosphatase, serum transaminase, serum bilirubin and lactic dehydrogenase.
Other adverse reactions are:
Gastrointestinal: duodenal ulcer, duodenitis, gastritis, bleeding, gastroenteritis, glossitis, pharyngitis, anorexia, cramps, abdominal pain;possible intra- and extrahepatic biliary sclerosis, as well as acalculous cholecystitis.
Cardiovascular: myocardial ischemia.
Laboratory Abnormalities: BSP, prothrombin, total proteins, sedimentation rate and thrombopenia.
Procedural Complications of Regional Arterial Infusion: arterial aneurysm; arterial ischemia; arterial thrombosis; embolism; fibromyositis; thrombophlebitis; hepatic necrosis; abscesses; infection at catheter site;bleeding at catheter site;catheter blocked, displaced or leaking.
The following adverse reactions have not been reported with floxuridine but have been noted following the administration of 5-fluorouracil. While the possibility of these occurring following floxuridine therapy is remote because of its regional administration, one should be alert for these reactions following the administration of floxuridine because of the pharmacological similarity of these two drugs: pancytopenia, agranulocytosis, myocardial ischemia, angina, anaphylaxis, generalized allergic reactions, acute cerebellar syndrome, nystagmus, headache, dry skin, fissuring, photosensitivity, pruritic maculopapular rash, increased pigmentation of the skin, vein pigmentation, lacrimal duct stenosis, visual changes, lacrimation, photophobia, disorientation, confusion, euphoria, epistaxis and nail changes, including loss of nails.
Read the entire FDA prescribing information for floxuridine (Floxuridine)
Additional Floxuridine Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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