"The U.S. Food and Drug Administration today approved Blincyto (blinatumomab) to treat patients with Philadelphia chromosome-negative precursor B-cell acute lymphoblastic leukemia (B-cell ALL), an uncommon form of ALL.
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High doses of FLUDARA FOR INJECTION (see WARNINGS section) have been associated with an irreversible central nervous system toxicity characterized by delayed blindness, coma and death. High doses are also associated with severe thrombocytopenia and neutropenia due to bone marrow suppression. There is no known specific antidote for FLUDARA (fludarabine) FOR INJECTION overdosage. Treatment consists of drug discontinuation and supportive therapy.
FLUDARA (fludarabine) FOR INJECTION is contraindicated in those patients who are hypersensitive to this drug or its components.This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 8/18/2010
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