Flunisolide Nasal Solution (Flunisolide Nasal Spray .025%) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

Pill Identifier Search

February 10, 2012

Flunisolide Nasal Solution

Allergy Drugs: Prescription and OTC »

Allergy medications overview

The arsenal of allergy drugs includes dozens of medications that relieve allergy symptoms when confronted with a trigger known as an allergen. That trigger could be something from a plant, such as pollen, or something from an animal (pet dander, dust mites, cockroaches). Other allergy triggers include certain fragrances or chemical substances.

What causes a person's allergic reaction is highly individual. But the reactions are often universal: swelling and inflammation, especially around the eyes, nose, and throat, usually accompanied by itching.

Some allergy medications work against the effects of histamines, which are released during an allergic reaction. Other medications reduce swelling, affect the immune system, or affect release of other substances associated with allergic reactions.

Many allergy drugs are available without a prescription.

For what conditions are allergy medicatio...

Read the Allergy Drugs: Prescription and OTC article »

Flunisolide Nasal Solution

10 Common Allergy Triggers Slideshow Pictures

Take the Quiz on Allergies

Nasal Allergy Relief Slideshow Pictures

font size

Flunisolide Nasal Solution USP, 0.025%
(Nasal Spray) (29 mcg flunisolide per spray)

For Intranasal Use Only

DRUG DESCRIPTION

Flunisolide, the active component of flunisolide nasal solution (flunisolide nasal spray .025%) , is an anti-inflammatory glucocorticosteroid with the chemical name: 6α-fluoro-11β,16α,17,21 tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone, hemihydrate. It has the following chemical structure:

Flunisolide structural formula illustration

Flunisolide is a white to creamy white crystalline powder with a molecular weight of 443.51 and molecular formula of C₂₄H₃₁FO₆. It is soluble in acetone, sparingly soluble in chloroform, slightly soluble in methanol, and practically insoluble in water. It has a melting point of about 245°C. The octanol:water partition coefficient is 2.17 at neutral pH.

Flunisolide nasal solution (flunisolide nasal spray .025%) is a metered dose manual pump spray unit containing 0.025% w/w flunisolide in an aqueous medium containing benzalkonium chloride, butylated hydroxytoluene, citric acid, edetate disodium, polyethylene glycol 400, polysorbate 20, propylene glycol, sodium citrate, sorbitol and purified water. Sodium hydroxide and/or hydrochloric acid may be added to adjust the pH to 4.5 to 6.0. Each 25 mL spray bottle contains 6.25 mg of flunisolide.

After initial priming (5 to 6 sprays), each spray of the pump spray unit delivers a metered spray of 100 mg formulation containing 29 mcg of flunisolide. The size of 99.5% of the droplets produced by the unit is greater than 8 microns. The contents of one nasal spray bottle delivers 200 sprays in addition to the priming sprays.

Last reviewed on RxList: 12/30/2008
This monograph has been modified to include the generic and brand name in many instances.