DermOtic® Oil Ear Drops contain fluocinolone acetonide {(6α,11β,16α)-6,9-difluoro-11,21-dihydroxy- 16,17[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione, cyclic 16,17 acetal with acetone}, a synthetic
corticosteroid. This formulation is also marketed as Derma-Smoothe/FS Body Oil® for the treatment of
atopic dermatitis and Derma-Smoothe/FS Scalp Oil® for the treatment of
psoriasis of the scalp. Chemically, fluocinolone acetonide is C24H30F2O6. It has the following structural formula:
Fluocinolone acetonide in DermOtic® Oil (fluocinolone acetonide oil ear drops) has a molecular weight of 452.50. It is a white crystalline powder that is odorless, stable in light, and melts at 270°C with decomposition; soluble in alcohol, acetone and methanol; slightly soluble in chloroform; insoluble in water.
Each gram of DermOtic® Oil contains approximately 0.11 mg of fluocinolone acetonide in a blend of oils, which contains isopropyl alcohol, isopropyl myristate, light mineral oil, oleth-2, refined peanut oil NF and fragrances.
Last reviewed on RxList: 3/3/2009
This monograph has been modified to include the generic and brand name in many instances.