Fluoroplex (Fluorouracil Topical Cream) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 27, 2012

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Fluoroplex

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FLUOROPLEX®
(fluorouracil) 1% Topical Cream

DRUG DESCRIPTION

FLUOROPLEX® (fluorouracil) 1% Topical Cream is an antineoplastic/antimetabolite product for dermatological use. Fluorouracil has the empirical formula C4H3FN2O2 and a molecular weight of 130.08. It is sparingly soluble in water and slightly soluble in alcohol. The pH is approximately 8.5.

Structural Formula:

fluorouracil

Chemical Name:

2,4(1H,3H)-Pyrimidinedione, 5-fluoro-.

FLUOROPLEX (fluorouracil topical cream) ® 1% Topical Cream contains:

Active Ingredient: fluorouracil 1.0%

Inactive Ingredients: benzyl alcohol, emulsifying wax, isopropyl myristate, mineral oil, purified water, and sodium hydroxide .

What are the possible side effects of fluorouracil topical (Carac, Efudex, Fluoroplex)?

Serious side effects are not likely to occur. Stop using fluorouracil topical and seek emergency medical attention if you experience an allergic reaction (shortness of breath; closing of your throat; swelling of your lips, face, or tongue; or hives).

Fluorouracil topical may cause skin irritation, dryness, scaling or peeling (exfoliation), rash, and other local reactions. Eye irritation has also been reported. If these side effects are excessive or worsen with continued treatment, contact your doctor.

Side...

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What are the precautions when taking fluorouracil topical cream (Fluoroplex )?

Before using fluorouracil, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: a certain enzyme deficiency (dihydropyrimidine dehydrogenase - DPD).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: red/irritated/infected/open sores on skin.

This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective...

Read All Potential Precautions of Fluoroplex »

Last reviewed on RxList: 5/6/2009
This monograph has been modified to include the generic and brand name in many instances.