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Fluoroplex Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Fluoroplex (fluorouracil topical cream) is an antineoplastic/antimetabolite product that works by blocking the growth of abnormal cells that cause the skin condition used to treat scaly overgrowths of skin (actinic or solar keratoses), or in the treatment of superficial basal cell carcinoma. Common side effects of Fluoroplex include skin irritation, burning, redness, dryness, scaling, peeling (exfoliation), pain, swelling, tenderness, rash, or changes in skin color at the site of application. Other side effects of Fluoroplex include eye irritation (stinging, watering), trouble sleeping, irritability, temporary hair loss, or abnormal taste in the mouth.
Apply a sufficient dose of Fluoroplex to cover the entire face or other affected areas. Apply medication twice daily with fingertips and wash hands afterwards. Treatment for 2-6 weeks is usually required. Fluoroplex may interact with other prescription or over-the-counter skin products. Do not use these products unless directed by your doctor. Tell your doctor all medications and supplements you use. Fluoroplex must not be used during pregnancy. It may harm a fetus. If you become pregnant or think you may be pregnant, inform your doctor. Consult your doctor about birth control. It is unknown if this medication passes into breast milk. Due to the potential risk to a nursing infant, breastfeeding is not recommended while using this drug.
Our Fluoroplex (fluorouracil topical cream) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Fluoroplex in Detail - Patient Information: Side Effects
Serious side effects are not likely to occur. Stop using fluorouracil topical and seek emergency medical attention if you experience an allergic reaction (shortness of breath; closing of your throat; swelling of your lips, face, or tongue; or hives).
Fluorouracil topical may cause skin irritation, dryness, scaling or peeling (exfoliation), rash, and other local reactions. Eye irritation has also been reported. If these side effects are excessive or worsen with continued treatment, contact your doctor.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Fluoroplex (Fluorouracil Topical Cream)
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Fluoroplex Overview - Patient Information: Side Effects
If any of these effects persist or worsen, contact your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor immediately if any of these rare but very serious side effects occur: stomach/abdominal pain, bloody diarrhea, vomiting, signs of infection (e.g., fever, chills, persistent sore throat), easy bruising/bleeding, mouth sores.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Fluoroplex (Fluorouracil Topical Cream)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Fluoroplex FDA Prescribing Information: Side Effects
Additional Fluoroplex Information
Fluoroplex - User Reviews
Fluoroplex User Reviews
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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