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Fluothane (halothane, USP) is supplied as a liquid and is vaporized for use as an inhalation anesthetic. It is 2-bromo-2-chloro-1, 1, 1-trifluoro-ethane. C 2 HBrClF 3
* Klaus Florey, editor, Analytical Profiles of Drug Substances, Vol. 1, page 127, (1972).
The specific gravity is 1.872-1.877 at 20°C, and the boiling point (range) is 49°C-51°C at 760 mm Hg. The vapor pressure is 243 mm Hg at 20°C. The blood/gas coefficient is 2.5 at 37°C, and the olive oil/water coefficient is 220 at 37°C. Vapor concentrations within anesthetic range are nonirritating and have a pleasant odor.
Fluothane (halothane) is nonflammable, and its vapors mixed with oxygen in proportions from 0.5 to 50% (v/v) are not explosive.
Fluothane (halothane) does not decompose in contact with warm soda lime. When moisture is present, the vapor attacks aluminum, brass, and lead, but not copper. Rubber, some plastics, and similar materials are soluble in Fluothane (halothane) ; such materials will deteriorate rapidly in contact with Fluothane (halothane) vapor or liquid. Stability of Fluothane (halothane) is maintained by the addition of 0.01% thymol (w/w), up to 0.00025% ammonia (w/w).
Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.
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