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Fluress Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 1/29/2016

Fluress (fluorescein sodium and benoxinate hydrochloride) is a sterile ophthalmic solution combining a disclosing agent with an anesthetic agent used for eye procedures requiring a disclosing agent in combination with an anesthetic agent such as tonometry, gonioscopy, removal of corneal foreign bodies and other short corneal or conjunctival procedures. Common side effects of Fluress include temporary stinging and burning in the treated eye, eye irritation, or conjunctival redness.

The dosage of Fluress is 1 to 2 drops in each eye before operating. For deep ophthalmic anesthesia, the administration is 2 drops in each eye at 90-second intervals for 3 instillations. The use of an eye patch is recommended. Fluress may interact with other drugs. Tell your doctor all medications you use. Fluress should be taken during pregnancy only if clearly needed. Consult your doctor before breastfeeding.

Our Fluress (fluorescein sodium and benoxinate hydrochloride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Fluress FDA Prescribing Information: Side Effects
(Adverse Reactions)


Occasional temporary stinging, burning and conjunctival redness have been reported after use of ocular anesthetics, as well as a rare severe, immediate-type, apparently hyperallergic corneal reaction with acute, intense and diffuse epithelial keratitis, a gray, ground glass appearance, sloughing or large areas of necrotic epithelium, corneal filaments and sometimes, iritis with descemetitis.

Allergic contact dermatitis with drying and fissuring of the fingertips has been reported.

Read the entire FDA prescribing information for Fluress (Fluorescein and Benoxinate)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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