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dexmethylphenidate hydrochloride tablets
Focalin ® (dexmethylphenidate hydrochloride) is the d-threo-enantiomer of racemic methylphenidate hydrochloride, which is a 50/50 mixture of the d-threo and l-threo-enantiomers. Focalin is a central nervous system (CNS) stimulant, available in 3 tablet strengths. Each tablet contains dexmethylphenidate αphenyl-2-piperidineacetate hydrochloride, (R,R')-(+)-. Its empirical formula is C14H19NO2•HCl. Its molecular weight is 269.77 and its structural formula is:
Note: *=asymmetric carbon centers
Dexmethylphenidate hydrochloride is a white to off white powder. Its solutions are acid to litmus. It is freely soluble in water and in methanol, soluble in alcohol, and slightly soluble in chloroform and in acetone.
Focalin also contains the following inert ingredients: pregelatinized starch, lactose monohydrate, sodium starch glycolate, microcrystalline cellulose, magnesium stearate, and FD&C Blue No.1 #5516 aluminum lake (2.5 mg tablets), D&C Yellow Lake #10 (5 mg tablets); the 10 mg tablet contains no dye.
What are the possible side effects of dexmethylphenidate (Focalin, Focalin XR)?
Get emergency medical help if you have any of these signs of an allergic reaction: fever; hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using dexmethylphenidate and call your doctor at once if you have any of these serious side effects:
- dangerously high blood pressure (severe headache, ringing in your ears, chest pain, numbness);
- seizure (convulsions);
- fast or uneven heart rate;
- blurred vision or other visual changes;
- unusual behavior, confusion; or
- twitching or...
What are the precautions when taking dexmethylphenidate hydrochloride (Focalin)?
Before taking dexmethylphenidate, tell your doctor or pharmacist if you are allergic to it; or to methylphenidate; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: high blood pressure, blood circulation problems (such as Raynaud's disease), glaucoma, heart problems (such as irregular heartbeat, heart failure, previous heart attack, problems with heart structure), family history of heart problems (such as sudden cardiac death, irregular heartbeat), mental/mood conditions (especially anxiety, tension, agitation), personal/family history of mental/mood...
Last reviewed on RxList: 5/6/2015
This monograph has been modified to include the generic and brand name in many instances.
Additional Focalin Information
Focalin - User Reviews
Focalin User Reviews
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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