DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some of the products that may interact with this drug include: other drugs that affect immune system (such as efalizumab, natalizumab), NSAIDs (such as ibuprofen, naproxen), probenecid, sulfa antibiotics (such as trimethoprim/sulfamethoxazole).

Check all prescription and nonprescription medicine labels carefully since many contain pain relievers/fever reducers (NSAIDs) which can increase the risk of side effects when used with pralatrexate. Ask your pharmacist about the safe use of those products.

OVERDOSE: If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call the US National Poison Hotline at 1-800-222-1222. Canada residents can call a provincial poison control center.

NOTES: Laboratory and/or medical tests (such as complete blood counts, liver function tests, kidney function tests) should be performed before you start treatment, periodically to monitor your progress, or to check for side effects.

MISSED DOSE: For the best possible benefit, it is important to receive each scheduled dose of this medication as directed. If you miss a dose, contact your doctor or pharmacist immediately to establish a new dosing schedule.

STORAGE: Not applicable. This medication is given in a hospital or clinic and will not be stored at home.

MEDICAL ALERT: Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-800-854-1166 (US) or 1-800-668-1507 (Canada).

Information last revised September 2010. Copyright(c) 2010 First Databank, Inc.