Fungizone (Amphotericin B) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

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FUNGIZONE
(amphotericin b) Injection, Powder, Lyophilized, for Solution

WARNING

This drug should be used primarily for treatment of patients with progressive and potentially life-threatening fungal infections; it should not be used to treat noninvasive forms of fungal disease such as oral thrush, vaginal candidiasis, and esophageal candidiasis in patients with normal neutrophil counts.

FUNGIZONE (amphotericin b) Intravenous should not be given at doses greater than 1.5 mg/kg. EXERCISE CAUTION to prevent inadvertent overdosage, which can result in potentially fatal cardiac or cardiopulmonary arrest (see WARNINGS, OVERDOSAGE, and DOSAGE AND ADMINISTRATION). Verify the product name and dosage if dose exceeds 1.5 mg/kg.

DRUG DESCRIPTION

FUNGIZONE Intravenous (Amphotericin B for Injection) contains amphotericin B, an antifungal polyene antibiotic obtained from a strain of Streptomyces nodosus. Amphotericin B is designated chemically as [1R- (1R*,3S*,5R*,6R*,9R*,11R*,15S*,16R*,17R*,18S*,19E,21E,23E,25E,27E,29E, 31E,33R*,35S*,36R*,37S*)]-33- [(3-Amino-3,6-dideoxy-β-D-mannopyranosyl)-oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid. Structural formula:

FUNGIZONE (amphotericin b) Structural Formula Illustration

C₄₇H₇₃NO₁₇ MW 924.09

Each vial contains a sterile, nonpyrogenic, lyophilized cake (which may partially reduce to powder following manufacture) providing 50 mg amphotericin B and 41 mg sodium desoxycholate with 20.2 mg sodium phosphate as a buffer. Crystalline amphotericin B is insoluble in water; therefore, the antibiotic is solubilized by the addition of sodium desoxycholate to form a mixture which provides a colloidal dispersion for intravenous infusion following reconstitution.

At the time of manufacture the air in the vial is replaced by nitrogen.

What are the possible side effects of amphotericin B (Fungizone, Fungizone For Tissue Culture)?

Some people receiving an amphotericin B injection have had a reaction to the infusion (either when the medicine is injected into the vein or within 1 to 3 hours afterward). Tell your caregiver right away if you feel dizzy, nauseated, light-headed, sweaty, feverish or cold, or if you have a slow heartbeat, chest tightness, or trouble breathing.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or...

Read All Potential Side Effects and See Pictures of Fungizone »

What are the precautions when taking amphotericin b (Fungizone)?

Before using amphotericin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: white blood cell (leukocyte) transfusions, heart disease (e.g., irregular heartbeat, congestive heart failure), liver disease, kidney disease.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Consult your doctor before...

Read All Potential Precautions of Fungizone »

Last reviewed on RxList: 4/8/2009
This monograph has been modified to include the generic and brand name in many instances.