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Fungizone Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Fungizone (amphotericin B) is an antifungal antibiotic used to treat serious, life-threatening fungal infections, and is usually given after other antifungal antibiotics have been unsuccessful. The brand name Fungizone is discontinued in the U.S. Generic forms may be available. Common side effects of Fungizone (amphotericin B) include injection site reactions (pain, swelling, irritation), fever, shaking, chills, flushing, loss of appetite, weight loss, dizziness, nausea, vomiting, diarrhea, upset stomach, headache, shortness of breath, muscle or joint aches, warmth/redness/tingly feeling under your skin, itching or rash, or fast breathing 1 to 3 hours after the infusion starts.
Dosage of amphotericin B is adjusted according to the patient's clinical status (e.g., site, cause, and severity of infection, heart and kidney function, etc.). A test dose is usually done to check for reaction, and therapy is usually initiated with a daily dose of 0.25 mg/ kg of body weight, given in a slow infusion over 2 to 6 hours. Amphotericin B may interact with flucytosine, digoxin, pentamidine, tacrolimus, muscle relaxers, steroids, antifungal antibiotics, antibiotics, antiviral medicines, or cancer medicine. Tell your doctor all medications you use. During pregnancy, Amphotericin B should be used only when prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.
Our Fungizone (amphotericin B) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Fungizone in Detail - Patient Information: Side Effects
Some people receiving an amphotericin B injection have had a reaction to the infusion (either when the medicine is injected into the vein or within 1 to 3 hours afterward). Tell your caregiver right away if you feel dizzy, nauseated, light-headed, sweaty, feverish or cold, or if you have a slow heartbeat, chest tightness, or trouble breathing.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Tell your doctor at once if you have any of these serious side effects:
- dry mouth, increased thirst, nausea, vomiting;
- extreme drowsiness, restless feeling, confusion;
- urinating more or less than usual, or not at all;
- muscle pain or weakness, fast or uneven heart rate, feeling light-headed, fainting;
- seizure (convulsions);
- fever, chills, body aches, flu symptoms;
- pale skin, easy bruising or bleeding, unusual weakness; or
- nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Less serious side effects may include:
- pain, swelling, or other irritation where the needle is placed;
- mild nausea, vomiting, diarrhea, upset stomach, loss of appetite;
- weight loss;
- muscle or joint aches;
- warmth, redness, or tingly feeling under your skin; or
- skin itching or mild rash.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Fungizone (Amphotericin B)
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Fungizone Overview - Patient Information: Side Effects
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: swelling/pain at injection site, muscle/joint pain, unusual tiredness, weakness, muscle cramping, change in the amount of urine, painful urination, numbness/tingling of arms/legs, vision changes, hearing changes (e.g., ringing in the ears), dark urine, severe stomach/abdominal pain, yellowing eyes/skin, swelling ankles/feet, fast/slow/irregular heartbeat, cold sweats, blue lips, easy bruising/bleeding, other signs of infection (e.g., fever, persistent sore throat), mental/mood changes, seizures, black stools, vomit that looks like coffee grounds.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Fungizone (Amphotericin B)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Fungizone FDA Prescribing Information: Side Effects
Although some patients may tolerate full intravenous doses of amphotericin B without difficulty, most will exhibit some intolerance, often at less than the full therapeutic dose.
Tolerance may be improved by treatment with aspirin, antipyretics (e.g., acetaminophen), antihistamines, or antiemetics. Meperidine (25 to 50 mg IV) has been shown in some patients to decrease the duration of shaking chills and fever that may accompany the infusion of amphotericin B.
Intravenous administration of small doses of adrenal corticosteroids just prior to or during the amphotericin B infusion may help decrease febrile reactions. Dosage and duration of such corticosteroid therapy should be kept to a minimum (see PRECAUTIONS: DRUG INTERACTIONS).
Extravasation may cause chemical irritation.
The adverse reactions most commonly observed are:
Hematologic: normochromic, normocytic anemia.
Local: pain at the injection site with or without phlebitis or thrombophlebitis.
Musculoskeletal: generalized pain, including muscle and joint pains.
Renal: decreased renal function and renal function abnormalities including: azotemia, hypokalemia, hyposthenuria, renal tubular acidosis; and nephrocalcinosis. These usually improve with interruption of therapy. However, some permanent impairment often occurs, especially in those patients receiving large amounts (over 5 g) of amphotericin B or receiving other nephrotoxic agents. In some patients hydration and sodium repletion prior to amphotericin B administration may reduce the risk of developing nephrotoxicity. Supplemental alkali medication may decrease renal tubular acidosis.
The following adverse reactions have also been reported:
General (body as a whole): flushing.
Allergic: anaphylactoid and other allergic reactions; bronchospasm; wheezing.
Altered Laboratory Findings
Renal Function Tests: Elevations of BUN and serum creatinine.
Read the entire FDA prescribing information for Fungizone (Amphotericin B)
Additional Fungizone Information
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