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Ganirelix Acetate Injection
Ganirelix Acetate Injection (ganirelix)
FOR SUBCUTANEOUS USE ONLY
Ganirelix Acetate Injection (ganirelix) is a synthetic decapeptide with high antagonistic activity against naturally occurring gonadotropin-releasing hormone (GnRH). Ganirelix Acetate is derived from native GnRH with substitutions of amino acids at positions 1, 2, 3, 6, 8, and 10 to form the following molecular formula of the peptide: N-acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-Dphenylalanyl-3-(3-pyridyl)-D-alanyl-L-seryl-L-tyrosyl-N9,N10-diethyl-D-homoarginyl-L-leucylN9,N10-diethyl-L-homoarginyl-L-prolyl-D-alanylamide acetate. The molecular weight for Ganirelix Acetate is 1570.4 as an anhydrous free base. The structural formula is as follows:
Ganirelix Acetate Injection (ganirelix) is supplied as a colorless, sterile, ready-to-use, aqueous solution intended for SUBCUTANEOUS administration only. Each sterile, prefilled syringe contains 250 µg/0.5 mL of Ganirelix Acetate, 0.1 mg glacial acetic acid, 23.5 mg mannitol, and water for injection adjusted to pH 5.0 with acetic acid, NF and/or sodium hydroxide, NF.
What are the possible side effects of ganirelix (Antagon, Ganirelix Acetate)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Some women using this medicine have developed a condition called ovarian hyperstimulation syndrome (OHSS), especially after the first treatment cycle. OHSS can be a life-threatening condition. Call your doctor right away if you have any of the following symptoms of OHSS:
- severe pelvic pain;
- swelling of the hands or legs;
- stomach pain and swelling;
- shortness of...
What are the precautions when taking ganirelix (Ganirelix Acetate Injection)?
Before using this medication, tell your doctor or pharmacist if you are allergic to it; or to other products containing gonadotropin releasing hormone (GnRH); or if you have any other allergies. This product may contain inactive ingredients (such as latex), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history.
Multiple births may occur because of this treatment program. Consult your doctor for more details.
This medication must not be used during pregnancy because of possible harm to an unborn baby. If you become pregnant or think you may be pregnant, inform your doctor immediately.
It is not known whether this drug passes into breast...
Last reviewed on RxList: 8/1/2008
This monograph has been modified to include the generic and brand name in many instances.
Additional Ganirelix Acetate Injection Information
Ganirelix Acetate Injection - User Reviews
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