Gantrisin (Acetyl Sulfisoxazole Pediatric Suspension) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 9, 2012

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Gantrisin

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GANTRISIN®
(acetyl sulfisoxazole) Pediatric Suspension

DRUG DESCRIPTION

Gantrisin (acetyl sulfisoxazole pediatric suspension) (sulfisoxazole) is an antibacterial sulfonamide available as a pediatric suspension for oral administration. Each teaspoonful (5 mL) of the pediatric suspension contains the equivalent of approximately 0.5 gm sulfisoxazole in the form of acetyl sulfisoxazole in a vehicle containing 0.3% alcohol, carboxymethylcellulose (sodium), citric acid, methylcellulose, parabens (methyl and propyl), partial invert sugar, sodium citrate, sorbitan monolaurate, sucrose, flavors and water.

Acetyl sulfisoxazole, the tasteless form of sulfisoxazole, is N¹-acetyl sulfisoxazole and must be distinguished from N⁴-acetyl sulfisoxazole, which is a metabolite of sulfisoxazole. Acetyl sulfisoxazole is a white or slightly yellow, crystalline powder that is slightly soluble in alcohol and practically insoluble in water. Acetyl sulfisoxazole has a molecular weight of 309.34 and the following structural formula:

GANTRISIN® (sulfisoxazole) Structural Formula Illustration

What are the possible side effects of sulfisoxazole (Gantrisin Pediatric)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

diarrhea that is watery or bloody;
fever, chills, body aches, flu symptoms;
cough, feeling short of breath, pale skin, joint pain, unusual bruising;
fast or pounding heartbeat;
blue lips or fingernails, feeling light-headed,...

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What are the precautions when taking acetyl sulfisoxazole pediatric suspension (Gantrisin)?

Before taking sulfisoxazole, tell your doctor or pharmacist if you are allergic to it; or to sulfa medications; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: a certain metabolic disorder (porphyria).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, severe allergies, asthma, diabetes, blood disorders (e.g., anemia due to folate vitamin deficiency), decreased bone marrow function (bone marrow suppression), a certain...

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Last reviewed on RxList: 9/16/2008
This monograph has been modified to include the generic and brand name in many instances.