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Gantrisin

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Gantrisin

Gantrisin Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Gantrisin (acetyl sulfisoxazole pediatric suspension) is a sulfonamide ("sulfa") antibiotic used to treat or prevent many different types of infections caused by bacteria, such as bladder infections, ear infections, or meningitis. The brand name of this medication is discontinued, but generic versions may be available. Common side effects include stomach pain, bloating, gas, headache, dizziness, ringing in your ears, or swollen, black, or "hairy" tongue.

The initial dose of Gantrisin for pediatric patients over 2 months of age is one half of the 24-hour dose. Maintenance dose: 150 mg/kg/24 hours or 4 gm/Mē/24 hours - dose to be divided into 4 to 6 doses/24 hours. Gantrisin may interact with blood thinners, methotrexate, or diabetes medications. Tell your doctor all medications and supplements you use. It is unknown if Gantrisin will harm a fetus. Gantrisin can cause jaundice (yellowing of the skin or eyes) and other problems in a newborn if the mother has taken this medication late in pregnancy. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. This drug can pass into breast milk and may harm a nursing baby. Do not breastfeed while you are taking Gantrisin, especially if your baby is younger than 2 months old.

Our Gantrisin (acetyl sulfisoxazole pediatric suspension) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Gantrisin in Detail - Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • diarrhea that is watery or bloody;
  • fever, chills, body aches, flu symptoms;
  • cough, feeling short of breath, pale skin, joint pain, unusual bruising;
  • fast or pounding heartbeat;
  • blue lips or fingernails, feeling light-headed, fainting;
  • swelling around your neck or throat;
  • urinating more or less than usual;
  • severe pain in your side or lower back, blood in your urine;
  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
  • agitation, confusion, unusual thoughts or behavior; or
  • seizure (black-out or convulsions).

Less serious side effects may include:

  • mild stomach pain, bloating, gas;
  • headache, dizziness;
  • ringing in your ears; or
  • swollen, black, or "hairy" tongue.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Gantrisin (Acetyl Sulfisoxazole Pediatric Suspension) »

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Gantrisin FDA Prescribing Information: Side Effects
(Adverse Reactions)

SIDE EFFECTS

The listing that follows includes adverse reactions both that have been reported with Gantrisin (acetyl sulfisoxazole pediatric suspension) and some which have not been reported with this specific drug; however, the pharmacologic similarities among the sulfonamides require that each of the reactions be considered with the administration of Gantrisin (acetyl sulfisoxazole pediatric suspension) .

Allergic/Dermatologic: Anaphylaxis, erythema multiforme (Stevens-Johnson syndrome), toxic epidermal necrolysis, exfoliative dermatitis, angioedema, arteritis and vasculitis, allergic myocarditis, serum sickness, rash, urticaria, pruritus, photosensitivity, and conjunctival and scleral injection, generalized allergic reactions and generalized skin eruptions. In addition, periarteritis nodosa and systemic lupus erythematosus have been reported (see WARNINGS).

Cardiovascular: Tachycardia, palpitations, syncope, cyanosis.

Endocrine: The sulfonamides bear certain chemical similarities to some goitrogens, diuretics (acetazolamide and thiazides) and oral hypoglycemia agents. Cross-sensitivity may exist with these agents. Development of goiter, diuresis and hypoglycemia have occurred rarely in patients receiving sulfonamides.

Gastrointestinal: Hepatitis, hepatocellular necrosis, jaundice, pseudomembranous colitis, nausea, emesis, anorexia, abdominal pain, diarrhea, gastrointestinal hemorrhage, melena, flatulence, glossitis, stomatitis, salivary gland enlargement, pancreatitis.

Onset of pseudomembranous colitis symptoms may occur during or after treatment with sulfisoxazole (see WARNINGS).

Sulfisoxazole has been reported to cause increased elevations of liver-associated enzymes in patients with hepatitis.

Genitourinary: Crystalluria, hematuria, BUN and creatinine elevations, nephritis and toxic nephrosis with oliguria and anuria. Acute renal failure and urinary retention have also been reported. The frequency of renal complications, commonly associated with some sulfonamides, is lower in patients receiving the more soluble sulfonamides such as sulfisoxazole.

Hematologic: Leukopenia, agranulocytosis, aplastic anemia, thrombocytopenia, purpura, hemolyticanemia, anemia, eosinophilia, clotting disorders including hypoprothrombinemia, and hypofibrinogenemia, sulfhemoglobinemia, methemoglobinemia.

Musculoskeletal: Arthralgia, myalgia.

Neurologic: Headache, dizziness, peripheral neuritis, paresthesia, convulsions, tinnitus, vertigo, ataxia, intracranial hypertension.

Psychiatric: Psychosis, hallucination, disorientation, depression, anxiety, apathy.

Respiratory: Cough, shortness of breath, pulmonary infiltrates (see WARNINGS).

Vascular: Angioedema, arteritis, vasculitis.

Miscellaneous:Edema (including periorbital), pyrexia, drowsiness, weakness, fatigue, lassitude, rigors, flushing, hearing loss, insomnia, pneumonitis, chills.

Read the entire FDA prescribing information for Gantrisin (Acetyl Sulfisoxazole Pediatric Suspension) »

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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