July 27, 2016
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GlucaGen

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GlucaGen

GlucaGen®
(glucagon [rDNA origin]) for Injection




DRUG DESCRIPTION

GlucaGen® (glucagon [rDNA origin] for injection) is an antihypoglycemic agent and a gastrointestinal motility inhibitor. It is produced by expression of recombinant DNA in a Saccharomyces cerevisiae vector with subsequent purification. The chemical structure of the glucagon in GlucaGen® is identical to human glucagon and to glucagon extracted from beef and pork pancreas. Glucagon with the empirical formula of C153H225N43O49S, and a molecular weight of 3483, is a single-chain polypeptide containing 29 amino acid residues. The structure of glucagon is:

GlucaGen® (glucagon) Structural Formula Illustration

GlucaGen® is a sterile, lyophilized white powder in a 2 mL vial (appearance of the powder may vary, and occasionally the powder may appear compacted). The reconstituted solution contains glucagon as hydrochloride 1 mg/mL (1 unit/mL) and lactose monohydrate (107 mg). GlucaGen® is supplied at pH 2.5-3.5 and is soluble in water.

What are the possible side effects of glucagon (GlucaGen, Glucagon Emergency Kit for Low Blood Sugar)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; fast or slow heartbeat; swelling of your face, lips, tongue, or throat.

Less serious side effects may include nausea or vomiting.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at...

Read All Potential Side Effects and See Pictures of GlucaGen »

Last reviewed on RxList: 2/16/2016
This monograph has been modified to include the generic and brand name in many instances.

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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