Glucotrol (Glipizide) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

Glucotrol

Diabetes (Type 1 and Type 2) »

Diabetes facts

Diabetes is a chronic condition associated with abnormally high levels of sugar (glucose) in the blood.
Insulin produced by the pancreas lowers blood glucose.
Absence or insufficient production of insulin causes diabetes.
The two types of diabetes are referred to as type 1 (insulin dependent) and type 2 (non-insulin dependent).
Symptoms of diabetes include increased urine output, thirst and hunger as well as fatigue.
Diabetes is diagnosed by blood sugar (glucose) testing.
The major complications of diabetes are both acute and chronic.
- Acutely: dangerously elevated blood sugar, abnormally low blood sugar due to diabetes medications may occur.
- Chronically: disease of the blood vessels (both small and large) which can damage the eye, kidneys, nerves, and heart may occur
Diabetes treatment depends...

Read the Diabetes (Type 1 and Type 2) article »

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GLUCOTROL®
(glipizide) Tablets

For Oral Use

DRUG DESCRIPTION

GLUCOTROL (glipizide) is an oral blood-glucose-lowering drug of the sulfonylurea class.

The Chemical Abstracts name of glipizide is l-cyclohexyl-3-[[p-[2-(5-methyrpyrazine-carboxamido)ethyl]phenyl]sulfonyl]urea. The molecular formula is C₂₁H₂₇N₅O₄S; the molecular weight is 445.55; the structural formula is shown below:

GLUCOTROL®
(glipizide) Structural Formula Illustration

Glipizide is a whitish, odorless powder with a pKa of 5.9. It is insoluble in water and alcohols, but soluble in 0.1 NNaOH; it is freely soluble in dimethylformamide. GLUCOTROL (glipizide) tablets for oral use are available in 5 and 10 mg strengths.

Inert ingredients are: colloidal silicon dioxide; lactose; microcrystalline cellulose; starch; stearic acid.

What are the possible side effects of glipizide (GlipiZIDE XL, Glucotrol, Glucotrol XL)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Hypoglycemia, or low blood sugar, is the most common side effect of glipizide. Symptoms of low blood sugar may include headache, nausea, hunger, confusion, drowsiness, weakness, dizziness, blurred vision, fast heartbeat, sweating, tremor, trouble concentrating, confusion, or seizure (convulsions). Watch for signs of low blood sugar. Carry a piece...

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What are the precautions when taking glipizide (Glucotrol)?

Before taking glipizide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: metabolic conditions (e.g., diabetic ketoacidosis).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, thyroid disease, certain hormonal conditions (adrenal/pituitary insufficiency, SIADH-syndrome of inappropriate secretion of antidiuretic hormone), electrolyte imbalance...

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Last reviewed on RxList: 4/4/2011
This monograph has been modified to include the generic and brand name in many instances.