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Glucovance Drug Center

Glucovance (glyburide and metformin HC1) is for people with type 2 diabetes who do not use daily insulin injections. This medication is not for treating type 1 diabetes. Glucovance is a combination of two oral diabetes medicines that help control blood sugar levels. This medication is available in generic form. Common side effects include nausea, stomach upset, diarrhea, or weight gain.

Dosage of Glucovance is individualized based on both effectiveness and tolerance. The maximum recommended daily dose should not exceed 20 mg glyburide/2000 mg metformin. Drugs that can raise blood sugar such as isoniazid, diuretics (water pills), steroids, phenothiazines, thyroid medicine, birth control pills, hormones, seizure medicines, and diet pills, or medicines to treat asthma, colds or allergies can lead to hyperglycemia (high blood sugar) when taken with Glucovance. Drugs that lower blood sugar such as non-steroidal anti-inflammatory drugs (NSAIDs), aspirin or other salicylates, sulfa drugs, monoamine oxidase inhibitors (MAOIs), beta-blockers, or probenecid may lead to hypoglycemia (low blood sugar) when taken with Glucovance. Other medications that may interfere with Glucovance include ciprofloxacin, furosemide, nifedipine, cimetidine or ranitidine, amiloride or triamterene, digoxin, morphine, procainamide, quinidine, trimethoprim, or vancomycin. During pregnancy, Glucovance should be used only when prescribed. If you are using this medication during your pregnancy, your doctor may switch you to insulin at least 2 weeks before the expected delivery date because of the risk of low blood sugar in your newborn. This drug passes into breast milk in small amounts. Consult your doctor before breast-feeding.

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