"What are oral diabetes medications and how do they work?
Insulin is a hormone produced by cells in the pancreas called beta cells. Insulin helps the body use blood glucose (a type of sugar) for energy. People with type 2 diabetes "...
- Clinician Information:
Glynase PresTab Patient Information including How Should I Take
In this Article
- What is glyburide (Glynase PresTab)?
- What are the possible side effects of glyburide (Glynase PresTab)?
- What is the most important information I should know about glyburide (Glynase PresTab)?
- What should I discuss with my health care provider before taking glyburide (Glynase PresTab)?
- How should I take glyburide (Glynase PresTab)?
- What happens if I miss a dose (Glynase PresTab)?
- What happens if I overdose (Glynase PresTab)?
- What should I avoid while taking glyburide (Glynase PresTab)?
- What other drugs will affect glyburide (Glynase PresTab)?
- Where can I get more information?
What should I discuss with my health care provider before taking glyburide (Glynase PresTab)?
You should not use this medication if you are allergic to glyburide, or:
- if you are being treated with bosentan (Tracleer);
- if you have type 1 (insulin-dependent) diabetes; or
- if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).
To make sure you can safely take glyburide, tell your doctor if you have any of these other conditions:
- hemolytic anemia (a lack of red blood cells);
- an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD);
- a nerve disorder affecting bodily functions;
- liver or kidney disease;
- if you are allergic to sulfa drugs; or
- if you have been using insulin or taking chlorpropamide (Diabinese).
Certain oral diabetes medications may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of treating your diabetes with glyburide.
FDA pregnancy category C. It is not known whether glyburide will harm an unborn baby. Similar diabetes medications have caused severe hypoglycemia in newborn babies whose mothers had used the medication near the time of delivery. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.
It is not known whether glyburide passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Older adults may be more likely to have low blood sugar while taking glyburide.
How should I take glyburide (Glynase PresTab)?
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results.
Take glyburide with your first meal of the day, unless your doctor tells you otherwise.
Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office. Visit your doctor regularly.
Know the signs of low blood sugar (hypoglycemia) and how to recognize them: headache, hunger, weakness, sweating, tremor, irritability, or trouble concentrating.
Always keep a source of sugar available in case you have symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. If you have severe hypoglycemia and cannot eat or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon emergency injection kit and tell you how to give the injection.
Also watch for signs of blood sugar that is too high (hyperglycemia). These symptoms include increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss.
Check your blood sugar carefully during a time of stress or illness, if you travel, exercise more than usual, drink alcohol, or skip meals. These things can affect your glucose levels and your dose needs may also change.
Your doctor may want you to stop taking glyburide for a short time if you become ill, have a fever or infection, or if you have surgery or a medical emergency.
Ask your doctor how to adjust your glyburide dose if needed. Do not change your medication dose or schedule without your doctor's advice.
If there are any changes in the brand, strength, or type of glyburide you use, your dosage needs may change. Always check your refills to make sure you have received the correct brand and type of medicine prescribed by your doctor.
Store at room temperature, protected from moisture, heat, and light.
Additional Glynase PresTab Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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