Goldenseal

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Are there any interactions with medications?



Cyclosporine (Neoral, Sandimmune)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The body breaks down cyclosporine (Neoral, Sandimmune) to get rid of it. Goldenseal might decrease how fast the body breaks down cyclosporine (Neoral, Sandimmune). This might cause there to be too much cyclosporine (Neoral, Sandimmune) in the body and could potentially cause side effects.



Digoxin (Lanoxin)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Taking goldenseal with digoxin (Lanoxin) might cause a very slight increase in digoxin (Lanoxin) levels in the body. But this does not seem to be an important interaction.



Medications changed by the liver (Cytochrome P450 2D6 (CYP2D6) substrates)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Some medications are changed and broken down by the liver. Goldenseal might decrease how quickly the liver breaks down some medications. Taking goldenseal along with some medications that are changed by the liver can increase the effects and side effects of your medication. Before taking goldenseal, talk to your healthcare provider if you take any medications that are changed by the liver.

Some medications that are changed by the liver include amitriptyline (Elavil), clozapine (Clozaril), codeine, desipramine (Norpramin), donepezil (Aricept), fentanyl (Duragesic), flecainide (Tambocor), fluoxetine (Prozac), meperidine (Demerol), methadone (Dolophine), metoprolol (Lopressor, Toprol XL), olanzapine (Zyprexa), ondansetron (Zofran), tramadol (Ultram), trazodone (Desyrel), and others.



Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Some medications are changed and broken down by the liver. Goldenseal might decrease how quickly the liver breaks down some medications. Taking goldenseal along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking goldenseal, talk to your healthcare provider if you are taking any medications that are changed by the liver.

Some medications changed by the liver include lovastatin (Mevacor), clarithromycin (Biaxin), indinavir (Crixivan), sildenafil (Viagra), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.



Medications moved by pumps in cells (P-Glycoprotein Substrates)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Some medications are moved by pumps in cells. Goldenseal might make these pumps less active and increase the amount of some medications that get absorbed by the body. This might increase the amount of some medications in the body, which could lead to more side effects. But there is not enough information to know if this is a big concern.

Some medications that are moved by these pumps include etoposide, paclitaxel, vinblastine, vincristine, vindesine, ketoconazole, itraconazole, amprenavir, indinavir, nelfinavir, saquinavir, cimetidine, ranitidine, diltiazem, verapamil, corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others.

Dosing considerations for Goldenseal.

The appropriate dose of goldenseal depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for goldenseal. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.


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