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PATIENT INSTRUCTIONS FOR USE FOR GONAL-F® RFF (follitropin alfa injection)
Step 1: Mixing (reconstituting) the vial containing Gonal-f® RFF (follitropin alfa injection)
|1. Wash your hands with soap and water.|
|2. Prepare a clean, flat surface for mixing your Gonal-f® RFF vials. Place alcohol wipes on the surface within easy reach.|
|3. Using your thumb, flip off the plastic cap of the Gonal-f® RFF vial(s).|
|4. Wipe the top of the vial stopper with an alcohol wipe.|
|5. Remove the wrapping from the 18G 1-½" pink mixing needle.|
|6. Carefully remove the protective cap off the pre-filled syringe labeled "sterile water for injection, USP". Twist the mixing needle on the prefilled syringe until it is tightened and remove the needle cap.|
|7. Position the 18G 1-½" needle of the syringe of water in a straight, upright position over the marked center circle of the rubber stopper on the vial of Gonal-f® RFF powder. Keep the 18G 1-½" needle at a 90 degree angle to the rubber stopper as you insert it through the center circle, or it may be difficult to depress the plunger. Slowly inject the water into the vial by depressing the syringe plunger.|
|8. Leave the 18G 1-½" needle and syringe in the vial. Gently rotate the vial between your fingers until the powder is dissolved. Do not shake the vial. If bubbles appear, wait a few moments for the bubbles to settle. The liquid drug should be clear.|
|9. Draw the total contents of the vial into the syringe. If necessary, invert the vial and pull back the 18G 1-½" needle as far as needed to withdraw the entire contents of the vial. Remove the 18G 1-½" needle and syringe containing the solution from the vial.|
|10. If more than one vial of powder medication is to be dissolved repeat steps 3, 4 and 7 to 9. A new alcohol wipe should be used to clean each vial. Use the same 18G 1-½" needle and syringe now containing reconstituted solution to reconstitute the additional vial(s). (Discard any other unused syringes of water for injection.)|
|11. Gently pull the plunger back to allow a small air space. Carefully recap the needle. Twist off the mixing needle from the syringe and discard safely.|
Step 2: Determining your dose on the injection syringe
Your doctor will instruct you to take a specific dose of Gonal-f® RFF (follitropin alfa injection) .
Step 3: Preparing your dose
|12. Remove the wrapping from the 29G ½" red injection needle. Twist the injection needle on the syringe and remove the need cap.|
|13. Invert the syringe with the 29G ½" needle for injection facing up toward the ceiling, gently tap the syringe, and push the plunger until all air bubbles have been expelled. This step may need to be repeated if all air bubbles are not expelled. Slightly depress the plunger until a drop of liquid is release from the tip of the needle.||
|14. Recap the 29G ½" needle for injection while preparing the injection site. Carefully lay the syringe on a flat, clean surface. Do not touch the needle or allow the needle to touch any surface.||
You should now be ready to prepare to receive the injection.
Step 4: Injecting your dose
|Your doctor, nurse, or pharmacist should provide you with injection training. Inject the prescribed dose as directed. Usual injection sites include the skin on the stomach, upper arm, or upper leg. Change the injection location each day to minimize discomfort.|
15. All needles should be disposed of in an appropriate needle disposal container as directed by the doctor.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
Last reviewed on RxList: 7/26/2007
This monograph has been modified to include the generic and brand name in many instances.
Additional Gonal-f RFF Information
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